Evidence map›Paper›PMID 41515186›Full record

ReviewNutrients2025

Polyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases.

Angela D'Angelo, Giuseppe Giannaccare, Filippo Lixi, Mario Troisi, Ginevra Giovanna Adamo, Deokho Lee, Ilaria De Pascale, Alfonso Pellegrino, Livio Vitiello

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angela D'AngeloDepartment of Clinical Sciences and Community Health, Department of Excellence 2023-2027, University of Milan, 20122 Milan, Italy.
Giuseppe GiannaccareEye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0003-2617-0289
Filippo LixiEye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.ORCID 0009-0008-0956-4925
Mario TroisiEye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80138 Naples, Italy.ORCID 0000-0003-3492-014X
Ginevra Giovanna AdamoDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Deokho LeeThe Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Republic of Korea.ORCID 0000-0002-5992-9039
Ilaria De PascaleEye Unit, "Luigi Curto" Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, Italy.
Alfonso PellegrinoEye Unit, "Luigi Curto" Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, Italy.
Livio VitielloEye Unit, "Luigi Curto" Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, Italy.ORCID 0000-0001-7867-3342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The worldwide burden of visual impairment is mostly attributed to ocular diseases, which include alterations of the retina, optic nerve, cornea, and ocular surface. Despite advances in medicine, the prevention and management of these conditions remain challenging, driving ongoing research into novel bioactive compounds. Among these, polyphenols-an assorted group of plant-derived compounds abundant in the human diet-have attracted significant attention due to their potential antioxidant, anti-inflammatory, and immunomodulatory properties. Increasing evidence suggests that polyphenols may help counteract oxidative stress and modulate pathways involved in ocular pathologies, assisting the conventional therapeutic strategies. This narrative review aims to analyze the current evidence about the potential therapeutic effects of the main polyphenols (e.g., curcumin, resveratrol, epigallocatechin gallate) currently recognized for the management of ocular diseases.

Indexed as

EyeEye DiseasesPolyphenolsAnimalsAnthocyaninsCatechinCoumaric AcidsCurcuminCysteineFlavonoidsHumansQuercetinResveratrol2'-cysteinyl-epigallocatechin-3-gallateAnthocyaninsbaicalinCatechinCoumaric AcidsCurcuminCysteineferulic acidFlavonoidsPolyphenolsQuercetinResveratrolanthocyaninscurcuminepigallocatechin gallateeye diseasesflavonoidspolyphenolsquercetinresveratrol

Identifiers

PMID41515186
PMCPMC12787918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.