Evidence map›Paper›PMID 41515190›Full record

ArticleNutrients2025

Dose-Sparing Efficacy of d-Limonene with Low-Dose Allopurinol in a Dual Model of Hyperuricemia and Gouty Arthritis in Rats.

Krishnaraju Venkatesan, Pooja Muralidharan, Durgaramani Sivadasan, Manimekalai Pichaivel, Yahya I Asiri, Khalid A Asseri, Nizar Sirag, Hassabelrasoul Elfadil, Mahmoud Elodemi, Kousalya Prabahar and 2 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Krishnaraju VenkatesanDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.
Pooja MuralidharanUndergraduate Program, PSG College of Pharmacy, Peelamedu, Coimbatore 641004, India.
Durgaramani SivadasanDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jizan 45142, Saudi Arabia.
Manimekalai PichaivelDepartment of Pharmacology, Swamy Vivekanadha College of Pharmacy, Elayampalayam, Nammakkal 637205, India.
Yahya I AsiriDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-8466-8694
Khalid A AsseriDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.
Nizar SiragDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-5453-6332
Hassabelrasoul ElfadilDivision of Microbiology, Immunology and Biotechnology, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-7964-1294
Mahmoud ElodemiPharmacology Department, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-5744-7773
Kousalya PrabaharDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
Premalatha PaulsamyCollege of Nursing, Mahalah Branch for Girls King Khalid University, Khamis Mushayt 61421, Saudi Arabia.ORCID 0000-0001-5117-480X
Kumarappan ChidambaramDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-7981-4562

Funding

Deanship of Scientific Research at King Khalid University RGP 2/408/46
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AllopurinolArthritis, GoutyCyclohexenesHyperuricemiaLimoneneTerpenesAnimalsAnti-Inflammatory AgentsAntioxidantsCytokinesDisease Models, AnimalDose-Response Relationship, DrugFemaleOxidative StressOxonic AcidRatsAllopurinolAnti-Inflammatory AgentsAntioxidantsCyclohexenesCytokinesLimoneneOxonic Acidpotassium oxonateTerpenesUric AcidXanthine Oxidaseallopurinold-Limonenedose-sparing therapyfood-derived bioactivesgouty arthritishyperuricemiaNLRP3 inflammasomenutraceuticalsoxidative stressrat model

Identifiers

PMID41515190
PMCPMC12788065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.