Evidence mapPaperPMID 41515230Full record

ReviewNutrients2025

Targeting Uterine Quiescence: A Multitarget Strategy with Vitamin D, High Molecular Weight Hyaluronic Acid, Magnesium, and Palmitoylethanolamide to Prevent Preterm Birth.

Ilenia Mappa, Giuseppina Porcaro, Martina Derme, Giuseppe Rizzo

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilenia MappaDepartment of Maternal and Child Health Urological Sciences, Sapienza University, 00161 Rome, Italy.
Giuseppina PorcaroDepartment of Gynecology and Obstetrics, Women's Health Centre, 05100 Terni, Italy.
Martina DermeDepartment of Maternal and Child Health Urological Sciences, Sapienza University, 00161 Rome, Italy.ORCID 0000-0003-2500-4166
Giuseppe RizzoDepartment of Maternal and Child Health Urological Sciences, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-5525-4353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining a quiescent uterus until labor is of utmost importance for a successful pregnancy and still represents the most challenging issue in clinical practice. Despite the existence of standard approaches (short-term use of tocolytic agents or preventive use of vaginal progesterone), whose efficacy is still controversial, several natural molecules have garnered attention in recent years as an effective therapeutic approach in high-risk pregnancies and beyond. Despite inflammatory activation, premature contractility depends on several factors, since myometrial quiescence is a complex mechanism not fully understood. Therefore, the synergistic activity of different natural molecules could be an innovative approach for acting simultaneously and maintaining uterine quiescence.

Indexed as

EndocannabinoidsEthanolaminesHyaluronic AcidPremature BirthUterine ContractionUterusVitamin DAmidesAnimalsFemaleHumansMyometriumPalmitic AcidsPregnancyTocolytic AgentsAmidesEndocannabinoidsEthanolaminesHyaluronic AcidpalmidrolPalmitic AcidsTocolytic AgentsVitamin Dhigh molecular weight hyaluronic acidpalmitoylethanolamidephysiological pregnancypremature contractility preventionPTBvitamin D

Identifiers

PMID41515230
PMCPMC12787450

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.