Evidence map›Paper›PMID 41515268›Full record

ArticleNutrients2026

Hops (

Daniela Ramírez Ortega, Erick R Hernández Pérez, Montserrat Gutiérrez Magdaleno, Karla F Meza-Sosa, Lucia Pineda Calderas, María José Álvarez Silva, Gustavo I Vázquez Cervantes, Dinora F González Esquivel, Wendy Leslie González Alfonso, Javier Angel Navarro Cossio and 6 more

Abstract read
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Plants (Basel, Switzerland) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniela Ramírez OrtegaNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0001-8610-7404
Erick R Hernández PérezNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Montserrat Gutiérrez MagdalenoNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Karla F Meza-SosaNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0002-0095-2357
Lucia Pineda CalderasNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
María José Álvarez SilvaNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Gustavo I Vázquez CervantesNeuroimmunology Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Dinora F González EsquivelNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0001-8262-3399
Wendy Leslie González AlfonsoNeuroimmunology Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0009-0000-5737-858X
Javier Angel Navarro CossioNeuroimmunology Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Paulina Ovalle RodríguezNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Itamar FloresNeuroimmunology Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Alelí SalazarNeuroimmunology Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Saul Gómez-ManzoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.ORCID 0000-0003-2095-9182
Benjamín PinedaNeuroimmunology Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0002-1455-312X
Verónica Pérez de la CruzNeurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0002-1451-8754

Funding

Consejo de Investigación sobre Salud y Cerveza de México 110-19
6 · The paper itself

Abstract

background

objectiveIn this study, we aimed to evaluate whether a complete Hops extract could exert antioxidant and neuroprotective effects.

methodsFirst, the ability of Hops extract's free radical scavenging capacity against superoxide, hydroxyl radical, and peroxynitrite was discovered using combinatorial chemical assays. Moreover, the used Hops extract prevented both DNA and protein degradation induced by hydroxyl radicals. Next, rats were orally administered with three different doses of Hops extract (10, 15, and 20 mg/kg/day) for 7 consecutive days.

resultsEx vivo analyses of brain tissues revealed that Hops pre-treatment attenuated FeSO

conclusionThese findings suggest that the whole Hops extract enhances redox resilience in the brain and confers protection against oxidative and excitotoxic insults.

Indexed as

AntioxidantsBrainHumulusNeuroprotective AgentsPlant ExtractsQuinolinic AcidAnimalsLipid PeroxidationMaleNF-E2-Related Factor 2Oxidation-ReductionOxidative StressRatsRats, Sprague-DawleyAntioxidantsNeuroprotective AgentsNF-E2-Related Factor 2Plant ExtractsQuinolinic Acidexcitotoxicityhopsneuroprotectionneurotoxicityredox resilience

Identifiers

PMID41515268
PMCPMC12787472

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.