ArticleMolecules (Basel, Switzerland)2025
Polyphenol-Enriched Fraction from Chestnut Shells as a Source of Bioactive Compounds for Friedreich Ataxia.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We explored the ability of the low molecular weight, polyphenol-rich fractions obtained from chestnut shells to inhibit ferroptosis in Friedreich Ataxia (FRDA), an inherited neuro- and cardio-degenerative disease. We prepared an aqueous extract by an eco-sustainable method and obtained a polyphenol-rich fraction (fraction D) of molecular weight less than 1.0 kDa after molecular size fractionation. The total phenols were 173.28 ± 4.97 μg gallic acid equivalents/mg fraction, and analysis by UHPLC-ITMS
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