Evidence map›Paper›PMID 41515885›Full record

ReviewInternational journal of molecular sciences2025

Cyanobacteria-Derived Extracellular Vesicles: A Novel Frontier in Drug Delivery and Therapeutics.

Khalid A Asseri, Krishnaraju Venkatesan, Yahya I Asiri, Saud Alqahtani, Taha Alqahtani, Pooja Muralidharan, Shaimaa Elsayed Ramadan Genena, Durgaramani Sivadasan, Premalatha Paulsamy, Kumarappan Chidambaram

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Khalid A AsseriDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0003-3559-5019
Krishnaraju VenkatesanDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0003-2853-5907
Yahya I AsiriDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-8466-8694
Saud AlqahtaniDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0009-0005-4587-0450
Taha AlqahtaniDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0003-4017-8754
Pooja MuralidharanUndergraduate Program, PSG College of Pharmacy, Peelamedu, Coimbatore 641004, India.
Shaimaa Elsayed Ramadan GenenaClinical Biochemistry Department, University of Tabuk, Tabuk 41477, Saudi Arabia.
Durgaramani SivadasanDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jizan 45142, Saudi Arabia.
Premalatha PaulsamyCollege of Nursing, Mahalah Branch for Girls, King Khalid University, Khamis Mushayt 61421, Saudi Arabia.ORCID 0000-0001-5117-480X
Kumarappan ChidambaramDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-7981-4562

Funding

the Deanship of Scientific Research at King Khalid University RGP 2/408/46
6 · The paper itself

Abstract

Cyanobacteria, known for their diverse and potent bioactive compounds, present a unique method for drug delivery via their extracellular vesicles (EVs), often described as exosome-like due to size and function but distinct in biogenesis. These naturally occurring vesicles, particularly those from cyanobacteria, are gaining attention as potential carriers for targeted drug delivery because of their biocompatibility, stability, and ability to encapsulate various bioactive compounds. However, cyanobacterial EVs remain underexplored as a dedicated nanocarrier platform, and their specific advantages and limitations relative to existing systems have not been systematically synthesized. This review explores the potential therapeutic uses of cyanobacterial EVs, emphasizing their roles in cancer treatment, antimicrobial therapies, neuroprotection, and immune modulation. We explore their biogenesis and structural features, comparing them to synthetic nanocarriers like polymeric nanoparticles and liposomes. The review also addresses the challenges of isolating and characterizing cyanobacterial EVs at scale and highlights the need for advancements in synthetic biology and genetic engineering to optimize their therapeutic potential. Despite these challenges, cyanobacterial EVs' unique properties offer significant promise for advancing drug delivery systems and providing innovative solutions for treating complex diseases.

Indexed as

CyanobacteriaDrug Delivery SystemsExtracellular VesiclesAnimalsDrug CarriersHumansNanoparticlesDrug Carriersbioactive compoundscyanobacterial EVsdrug delivery systemsnanocarrierstargeted therapeutics

Identifiers

PMID41515885
PMCPMC12785971

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.