ArticleInternational journal of molecular sciences2025
From Vascular Dysfunction to Atherothrombosis: The Pivotal Role of Eicosanoids and Their Receptors in Platelet and Endothelial Imbalance: A Scoping Review.
Giovanna Ritorto, Sara Ussia, Roberta Macrì, Maria Serra, Annamaria Tavernese, Carmen Altomare, Denise Maria Dardano, Chiara Idone, Ernesto Palma, Carolina Muscoli and 4 more
Abstract readScoping Review
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Giovanna RitortoPharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Sara UssiaPharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Roberta MacrìPharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-2345-6751 Maria SerraLaboratory of Mass Spectrometry and Proteomics, Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0009-0005-7736-2207 Annamaria TaverneseDepartment of Medicine and Surgery, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Carmen AltomarePharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0009-0000-8885-4622 Denise Maria DardanoPharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Chiara IdonePharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Ernesto PalmaVeterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-4199-207X Carolina MuscoliPharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-1047-4467 Maurizio VolterraniCardiology Department, IRCCS San Raffaele Roma, Via di Valcannuta 250, 00166 Rome, Italy.ORCID 0000-0002-2624-9213 Francesco BarillàDepartment of Experimental Medicine, University "Tor Vergata" of Rome, 00133 Rome, Italy.ORCID 0000-0003-0594-7212 Vincenzo MollacePharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-0392-7173 Rocco MollacePharmacology Laboratory, Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-7106-5595 Funding
miur PON-MIUR 03PE000_78_1miur PON-MIUR 03PE000_78_2prir PON-MIUR 03PE000_78_2, and PRIR Calabria Asse 1/Azione 1.5.1/FESR (Progetto AgrInfra Calabria)
6 · The paper itselfAbstract
Vascular endothelium balances antithrombotic and anti-inflammatory activity to control blood vessel tone under physiological conditions. However, endothelial dysfunction impairs these processes, causing a state that promotes clotting and inflammation. Eicosanoids are a major class of bioactive lipid mediators crucial for modulating endothelial and platelet function. Research has highlighted the roles of eicosanoids in vascular diseases, showing pro-inflammatory, prothrombotic, and protective activities. Specifically, prostaglandin E
Indexed as
AtherosclerosisBlood PlateletsEicosanoidsEndothelium, VascularThrombosisAnimalsHumansEicosanoidsatherothrombosiseicosanoid receptorseicosanoidsendothelial dysfunctionplatelet aggregationplatelet dysfunctionprostaglandins
Identifiers
PMID41516038
PMCPMC12786269
What Socratic holds
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