Evidence map›Paper›PMID 41516064›Full record

ArticleInternational journal of molecular sciences2025

Oral Nano-Delivery of Crotoxin Modulates Experimental Ulcerative Colitis in a Mouse Model of Maximum Acute Inflammatory Response.

Raquel Guedes de Oliveira Brito, Fernanda Narangeira de Araujo Neves, Larissa Ferreira de Almeida, Bruna Cristina Favoretto, Wafa Hanna Koury Cabrera, Nancy Starobinas, Jamile Macedo Garcia, Natália Coelho Couto de Azevedo Fernandes, José Luiz de Souza Lopes, Marcia Carvalho de Abreu Fantini and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Raquel Guedes de Oliveira BritoImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Fernanda Narangeira de Araujo NevesImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Larissa Ferreira de AlmeidaPhysics Institute, University of São Paulo, São Paulo 05508-220, Brazil.
Bruna Cristina FavorettoImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Wafa Hanna Koury CabreraImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Nancy StarobinasImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.ORCID 0000-0001-5716-3394
Jamile Macedo GarciaPathological Anatomy Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.ORCID 0009-0008-7737-6619
Natália Coelho Couto de Azevedo FernandesPathological Anatomy Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil.ORCID 0000-0003-4754-4200
José Luiz de Souza LopesDepartment of Physics, FFCLRP, University of São Paulo, Ribeirão Preto 14040-900, Brazil.ORCID 0000-0003-1281-0521
Marcia Carvalho de Abreu FantiniPhysics Institute, University of São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0001-6862-8716
Pedro Leonidas Oseliero FilhoPhysics Institute, University of São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0002-5711-1444
Olga Martinez IbañezImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.ORCID 0000-0002-2672-4758
Osvaldo Augusto Sant'AnnaImmunochemistry Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Solange MassaImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Orlando Garcia RibeiroImmunogenetics Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.ORCID 0000-0003-2117-2402

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/17844-8, 2019/12301-1
6 · The paper itself

Abstract

The incorporation of drugs into nanostructured silica has proven to be an effective strategy for delaying drug release, protecting against enzymatic degradation, and enhancing therapeutic efficacy. Specifically, crotoxin, a component derived from the venom of

Indexed as

Colitis, UlcerativeCrotoxinInflammationNanoparticlesAdministration, OralAnimalsDextran SulfateDisease Models, AnimalMaleMiceSilicon DioxideCrotoxinDextran SulfateSBA-15Silicon DioxidecrotoxinDSSinflammationmicesilica nanoparticlesulcerative colitis

Identifiers

PMID41516064
PMCPMC12785686

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.