Evidence map›Paper›PMID 41516065›Full record

ArticleInternational journal of molecular sciences2025

Exploring Spiders Without Venom as New Sources of Peptidase Inhibitors.

Jefferson O Silva, Ana Carolina O Silva, Rodrigo Valladão, Oscar Bento Neto, Vinicius Carius de Souza, Clelia Ferreira, Walter Ribeiro Terra, Adriana Rios Lopes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jefferson O SilvaBiotechnology Postgraduate Program, Institute of Biomedical Sciences, University of São Paulo, 2415 Professor Lineu Prestes Avenue, São Paulo 05508-000, Brazil.
Ana Carolina O SilvaBiotechnology Postgraduate Program, Institute of Biomedical Sciences, University of São Paulo, 2415 Professor Lineu Prestes Avenue, São Paulo 05508-000, Brazil.
Rodrigo ValladãoBiochemistry Laboratory, Butantan Institute, 1500 Vital Brazil Avenue, São Paulo 05503-900, Brazil.ORCID 0000-0003-3180-0046
Oscar Bento NetoBiochemistry Laboratory, Butantan Institute, 1500 Vital Brazil Avenue, São Paulo 05503-900, Brazil.
Vinicius Carius de SouzaSpecial Laboratory of Applied Toxinology, Butantan Institute, 1500 Vital Brazil Avenue, São Paulo 05503-900, Brazil.
Clelia FerreiraInstitute of Chemistry, Department of Biochemistry, University of São Paulo, 748 Professor Lineu Prestes Avenue, São Paulo 05508-000, Brazil.
Walter Ribeiro TerraInstitute of Chemistry, Department of Biochemistry, University of São Paulo, 748 Professor Lineu Prestes Avenue, São Paulo 05508-000, Brazil.
Adriana Rios LopesBiotechnology Postgraduate Program, Institute of Biomedical Sciences, University of São Paulo, 2415 Professor Lineu Prestes Avenue, São Paulo 05508-000, Brazil.ORCID 0000-0002-9741-2110

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/09103-4
6 · The paper itself

Abstract

Peptidases constitute at least 2% of genes in living organisms and participate in nearly all physiological processes across life forms. Conversely, peptidase inhibitors are essential for regulating proteolytic activity and have been widely applied. Combining high-throughput sequencing of novel peptidase inhibitor sources with molecular modeling and drug design currently represents an efficient strategy for developing new molecules. Venomous spiders harbor a wide array of peptidase inhibitors in both their venom and digestive system. However, biochemical and transcriptomic investigations of non-venomous spiders (Uloboridae) remain recent and scarce. Here, transcriptomic and biochemical analyses of the Uloboridae spider

Indexed as

Protease InhibitorsSpidersAnimalsPeptide HydrolasesSpider VenomsTranscriptomePeptide HydrolasesProtease InhibitorsSpider VenomsdigestioninhibitorspeptidasespidersstructuretranscriptomeUloboridae

Identifiers

PMID41516065
PMCPMC12785369

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.