Evidence map›Paper›PMID 41516073›Full record

ArticleInternational journal of molecular sciences2025

Hepatic FGF21 Deletion Improves Glucose Metabolism, Alters Lipogenic and

Daniel Torres-Oteros, Mariano Nicola-Llorente, Héctor Sanz-Lamora, Albert Pérez-Martí, Pedro F Marrero, Silvia Canudas, Diego Haro, Joana Relat

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel Torres-OterosDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0003-0445-028X
Mariano Nicola-LlorenteDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0003-4368-0352
Héctor Sanz-LamoraDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0003-0271-5280
Albert Pérez-MartíDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0003-3234-3756
Pedro F MarreroDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0002-6138-6731
Silvia CanudasDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0002-5630-1588
Diego HaroDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0001-9147-0486
Joana RelatDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences, Food Torribera Campus, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.ORCID 0000-0001-8974-1785

Funding

Fundación Española para la Ciencia y la Tecnología Crowdfunding Precipita.esGeneralitat de Catalunya 2021SGR 00861Ministerio de Ciencia, Innovación y Universidades AGL2017-82417-RMinisterio de Ciencia, Innovación y Universidades Ayuda María ZambranoMinisterio de Ciencia, Innovación y Universidades FPU19/02601Universitat de Barcelona PREDOCS-UB 2020
6 · The paper itself

Abstract

Fibroblast growth factor 21 (FGF21) is a key hormone for metabolic homeostasis under conditions such as obesity, aging and diabetes. While extensively studied in males, its role in female physiology remains poorly defined. This study evaluated the effects of hepatic FGF21 deletion in 12-month-old female mice using a liver-specific FGF21 knockout (FKO) model. FKO females exhibited reduced body weight and improved glucose tolerance, with no changes in circulating FGF21 levels. In the liver, RT-qPCR analysis showed that the expression of genes involved in de novo lipogenesis, including

Indexed as

AgingFibroblast Growth FactorsGlucoseLipogenesisLiverReceptors, NicotinicTelomere HomeostasisAnimalsFemaleGene DeletionGene Expression RegulationMiceMice, Knockoutfibroblast growth factor 21Fibroblast Growth FactorsGlucoseReceptors, NicotinicageingCHRNA4femalesFGF21livermetabolic healthtelomere length

Identifiers

PMID41516073
PMCPMC12786002

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.