Evidence map›Paper›PMID 41516093›Full record

ArticleInternational journal of molecular sciences2025

ILK Deletion Protects Against Chronic Kidney Disease-Associated Vascular Damage.

Sofía Campillo, Elena Gutiérrez-Calabrés, Susana García-Miranda, Mercedes Griera, Sergio de Frutos, Diego Rodríguez-Puyol, Laura Calleros

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sofía CampilloPhysiology Unit, Department of Systems Biology, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0001-5182-6396
Elena Gutiérrez-CalabrésPhysiology Unit, Department of Systems Biology, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0001-8144-6909
Susana García-MirandaPhysiology Unit, Department of Systems Biology, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0009-0006-7364-7421
Mercedes GrieraPhysiology Unit, Department of Systems Biology, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0002-9887-6638
Sergio de FrutosPhysiology Unit, Department of Systems Biology, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0002-1225-5911
Diego Rodríguez-PuyolFundación Renal Española, 28003 Madrid, Spain.ORCID 0000-0002-9125-9311
Laura CallerosPhysiology Unit, Department of Systems Biology, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0001-7739-1319

Funding

Comunidad de Madrid B2017/BMD-3751Comunidad de Madrid P2022/BMD-7221Comunidad de Madrid S2022/BMD-7221Instituto de Salud Carlos III PI17/00625Instituto de Salud Carlos III PI17/01513Instituto de Salud Carlos III PI20/00634Instituto de Salud Carlos III PI20/00664Instituto de Salud Carlos III PI22/01714Instituto de Salud Carlos III PI23/01071Instituto de Salud Carlos III RD21/0005/0023Instituto de Salud Carlos III RD24/0004/0020University of Alcalá PIUAH23/CCS-010; Art.60 LOSU 2022/024
6 · The paper itself

Abstract

Cardiovascular diseases are a major cause of morbidity and mortality in chronic kidney disease (CKD) patients. Integrin-linked kinase (ILK) regulates integrin-extracellular matrix interactions and vascular integrity. This study investigated the role of ILK in CKD-associated vascular alterations. An adenine-supplemented diet induced a progressive CKD in wild-type (WT) and conditional ILK knock-down (cKD-ILK) mice. Aortic tissue was collected for histology and RT-qPCR analysis. Moreover, aortas were incubated ex vivo with the uremic toxins

Indexed as

Gene DeletionProtein Serine-Threonine KinasesRenal Insufficiency, ChronicAnimalsAortaFibrosisHumansIndicanMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleScaffold Protein ILKUremic ToxinsIndicanProtein Serine-Threonine KinasesScaffold Protein ILKUremic Toxinschronic kidney disease (CKD)fibrosisILKinflammationvascular damage

Identifiers

PMID41516093
PMCPMC12785976

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.