ArticleInternational journal of molecular sciences2025
Biologically Informed Machine Learning Prioritizes Dietary Supplements That Protect Neural Crest Cells from Ethanol-Induced Epigenetic Dysregulation and Developmental Impairment.
Xiaoqing Wang, Miao Bai, Shuoyang Wang, Hongjia Qian, Jie Liu, Wenke Feng, Huang-Ge Zhang, Xiaoyang Wu, Shao-Yu Chen
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Xiaoqing WangDepartment of Pharmacology and Toxicology, Health Sciences Center, University of Louisville, Louisville, KY 40292, USA.
Miao BaiDepartment of Pharmacology and Toxicology, Health Sciences Center, University of Louisville, Louisville, KY 40292, USA.
Shuoyang WangDepartment of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-6963-6267 Hongjia QianDepartment of Pharmacology and Toxicology, Health Sciences Center, University of Louisville, Louisville, KY 40292, USA.
Jie LiuDepartment of Pharmacology and Toxicology, Health Sciences Center, University of Louisville, Louisville, KY 40292, USA.
Wenke FengDepartment of Structural and Cellular Biology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Huang-Ge ZhangDepartment of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40292, USA.
Xiaoyang WuBen May Department for Cancer Research, University of Chicago, Chicago, IL 60605, USA.
Shao-Yu ChenDepartment of Pharmacology and Toxicology, Health Sciences Center, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-7953-9700 Funding
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9MMechanisms of Probiotics in Alcoholic Liver DiseaseR01AA023190 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2015 to 2024
$3.5MIntestine FXR activation by LGG-derived nanoparticles in alcohol-associated liver diseaseR01AA030424 · NIAAA · UNIVERSITY OF LOUISVILLE · PI WENKE FENG · 2022 to 2026
$2.6MRole of exosomes in the coordinated migration of neural crest cells and placodes and ethanol-induced teratogenesisR01AA028435 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2020 to 2024
$1.8MNIAAA NIH HHS AA024337NIAAA NIH HHS AA028435NIAAA NIH HHS AA030424NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA023190NIAAA NIH HHS R01 AA028435NIAAA NIH HHS R01 AA030424
6 · The paper itselfAbstract
The impairment of neural crest cells (NCCs) plays a pivotal role in the pathogenesis of fetal alcohol spectrum disorders (FASD). Epigenetic regulators mediate ethanol-induced disruptions in NCC development and represent promising targets for nutritional interventions. Here, we developed a biologically informed machine learning framework to predict nutritional supplements that modulate five key epigenetic regulators (
Indexed as
Dietary SupplementsEpigenesis, GeneticEthanolFetal Alcohol Spectrum DisordersMachine LearningNeural CrestAnimalsHumansMicroRNAsPredictive Learning ModelsEthanolMicroRNAsartificial intelligencebiologically informed machine learning modelsepigeneticsfetal alcohol spectrum disorders (FASD)neural crest cells
Identifiers
PMID41516175
PMCPMC12785273
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