Evidence map›Paper›PMID 41516240›Full record

ReviewInternational journal of molecular sciences2025

From Gut Dysbiosis to Skin Inflammation in Atopic Dermatitis: Probiotics and the Gut-Skin Axis-Clinical Outcomes and Microbiome Implications.

Adina Elena Micu, Ioana Adriana Popescu, Ioana Alina Halip, Mădălina Mocanu, Dan Vâță, Andreea Luana Hulubencu, Dragoș Florin Gheucă-Solovăstru, Laura Gheucă-Solovăstru

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adina Elena MicuDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Ioana Adriana PopescuDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID 0000-0003-0447-3625
Ioana Alina HalipDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID 0000-0003-2587-7549
Mădălina MocanuDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Dan VâțăDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Andreea Luana HulubencuDepartment of Dermatology, "St. Spiridon" Emergency County Clinical Hospital, 700111 Iași, Romania.
Dragoș Florin Gheucă-SolovăstruDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Laura Gheucă-SolovăstruDepartment of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease in which barrier impairment, immune dysregulation, and gut-skin dysbiosis intersect, prompting growing interest in probiotics as microbiota-modulating adjuncts. We conducted a narrative review of peer-reviewed articles indexed in PubMed, Scopus, and Google Scholar, restricted to publications from 1 January 2018 to 31 October 2025 (searches last run in December 2025). Eligible evidence included randomized controlled trials (RCTs), observational studies, and mechanistic or conceptual reviews addressing microbiome alterations and microbiota-modulating interventions in AD. Most pediatric RCTs using multistrain,

Indexed as

Dermatitis, AtopicDysbiosisGastrointestinal MicrobiomeProbioticsSkinAnimalsHumansInflammationSkin Microbiomeatopic dermatitisdysbiosisgut–skin axismicrobiomeprobiotics

Identifiers

PMID41516240
PMCPMC12785343

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.