Evidence map›Paper›PMID 41516248›Full record

ArticleInternational journal of molecular sciences2025

Neuromodulatory Effects of Arecoline on Anxiety-like Behavior in Mice Exposed to Chronic Unpredictable Mild Stress.

Xiangfei Zhang, Danyang Wang, Jingwen Cui, Bei Fan, Fengzhong Wang, Cong Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangfei ZhangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Danyang WangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Jingwen CuiInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Bei FanInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Fengzhong WangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Cong LuInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Funding

Bei Fan 2022YFD1600303Cong Lu and Fengzhong Wang CAAS-ASTIP-2025-IFST
6 · The paper itself

Abstract

Chronic stress disrupts neuroendocrine regulation, neurotransmitter balance, and neuronal redox homeostasis, thereby contributing to the development of anxiety-related neuropathology. Arecoline, the predominant alkaloid of

Indexed as

Anti-Anxiety AgentsAnxietyArecolineBehavior, AnimalNeurotransmitter AgentsStress, PsychologicalAnimalsBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2CorticosteroneCyclic AMP Response Element-Binding ProteinDisease Models, AnimalHippocampusMaleMiceNeuronal PlasticityAnti-Anxiety AgentsArecolineBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2CorticosteroneCyclic AMP Response Element-Binding ProteinNeurotransmitter AgentsReceptors, N-Methyl-D-AspartateanxietyAreca catechuarecolinechronic unpredictable mild stresshippocampusneuroplasticityoxidative stress

Identifiers

PMID41516248
PMCPMC12785299

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.