Evidence map›Paper›PMID 41516251›Full record

ArticleInternational journal of molecular sciences2025

Acute Sleep Deprivation and the Autoimmune TLR-BANK1 Pathway: Interplay with Gender and Emotional State.

Marta Ditmer, Agata Gabryelska, Aleksandra Tarasiuk-Zawadzka, Agata Binienda, Szymon Turkiewicz, Filip Franciszek Karuga, Aleksandra Wojtera, Piotr Białasiewicz, Jakub Fichna, Dominik Strzelecki and 1 more

Abstract read
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marta DitmerDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Agata GabryelskaDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-4430-6488
Aleksandra Tarasiuk-ZawadzkaDepartment of Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Agata BiniendaDepartment of Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-1173-2966
Szymon TurkiewiczDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Filip Franciszek KarugaDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-6551-6804
Aleksandra WojteraDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0009-0005-1105-5298
Piotr BiałasiewiczDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.
Jakub FichnaDepartment of Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-8443-4417
Dominik StrzeleckiDepartment of Affective and Psychotic Disorders, Medical University of Lodz, 92-216 Lodz, Poland.ORCID 0000-0002-8559-1078
Marcin SochalDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0003-2122-0304

Funding

Medical University of Lodz (Poland) 503/1-156-04/503-11-001Medical University of Lodz (Poland) 564/1-000-00/564-20-062Ministry of Education and Science (Poland) PN/02/0093/2023Ministry of Education and Science (Poland) SKN/SP/629918/2025
6 · The paper itself

Abstract

Deprivation of sleep (DS) is linked to increased risk of immune-mediated diseases. Toll-like receptors (TLR7, TLR9) and BANK1 are key B-cell signaling components that may contribute to their pathogenesis. Seventy-six adults underwent polysomnography (PSG) followed by DS. Venous blood was collected after PSG and DS. Mood was evaluated before and after each stage using Montgomery-Åsberg Depression Rating Scale. Participants were classified as Responders (REs) or Non-Responders (NRs) based on mood changes post-DS. Gene mRNA expression of TLR7, TLR9, and BANK1 in peripheral blood mononuclear cells was analyzed by qRT-PCR. DS reduced TLR7 expression in the entire study group and within NRs, REs, and male and female subgroups (all

Indexed as

Adaptor Proteins, Signal TransducingMembrane ProteinsSleep DeprivationToll-Like Receptor 7Toll-Like Receptor 9AdultFemaleHumansMaleMiddle AgedPolysomnographySex FactorsSignal TransductionAdaptor Proteins, Signal TransducingMembrane ProteinsTLR7 protein, humanTLR9 protein, humanToll-Like Receptor 7Toll-Like Receptor 9BANK1sleepsleep deprivationTLR7TLR9

Identifiers

PMID41516251
PMCPMC12786070

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.