Evidence map›Paper›PMID 41516281›Full record

ArticleInternational journal of molecular sciences2025

Weighted Gene Co-Expression Network Analysis and Alternative Splicing Analysis Reveal Key Genes Regulating Overfeeding-Induced Fatty Liver in Lion-Head Goose.

Jing Fu, Yezhi Lan, Yuwen Liang, Xiaoguang Yang, Ruize Tang, Yuchuan Wang, Yabiao Luo, Chunpeng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing FuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yezhi LanSanya Institute, China Agricultural University, Sanya 572025, China.
Yuwen LiangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xiaoguang YangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.ORCID 0009-0004-5605-5470
Ruize TangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yuchuan WangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yabiao LuoState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, Frontiers Science Center for Molecular Design Breeding, Beijing Key Laboratory for Animal Genetic Improvement, China Agricultural University, Beijing 100193, China.
Chunpeng LiuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.

Funding

Department of Agriculture of Guangdong Province 2024-XPY-00-016
6 · The paper itself

Abstract

Lion-head goose is a large-sized breed native to Guangdong Province, China, exhibits remarkable capacity for fatty liver production under overfeeding conditions and is highly valued by local farmers and consumers. However, the molecular mechanisms driving fatty liver development in this breed are still unknown. In this study, we evaluated liver weight differences between normally fed and overfed Lion-head geese and further examined sex-specific differences following overfeeding. Overfeeding significantly increased liver weight more than 340%, and males possess a stronger capacity for lipid deposition under the same feeding regimen compared with females. RNA-Seq analysis identified 1476 differentially expressed genes (DEGs) shared by both sexes, which were mainly enriched in lipid and energy metabolism, oxidative stress, and mitochondrial pathways. In addition, 627 male-specific and 420 female-specific DEGs revealed sex-dependent differences, with males showing stronger transcriptional regulation and females exhibiting enhanced antioxidant and detoxification responses. Weighted gene co-expression network analysis (WGCNA) revealed 320 co-hub genes enriched in lipid and energy metabolism in overfeeding-induced fatty liver, along with 9 co-hub genes related to sex differences. Alternative splicing (AS) analysis detected 131 differentially spliced genes (DSGs). Integration of both approaches identified 7 overlapping genes,

Indexed as

Alternative SplicingFatty LiverGeeseGene Regulatory NetworksAnimalsFemaleGene Expression ProfilingGene Expression RegulationLipid MetabolismLiverMaleTranscriptomealternative splicingfatty liverLion-head gooseoverfeedingWGCNA

Identifiers

PMID41516281
PMCPMC12785810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.