RNA-Binding Proteins in Dinoflagellates.

The described features of dinoflagellate gene expression indicate the predominance of post-transcriptional and translational regulation over transcriptional control. These microorganisms also exhibit extensive RNA editing and distinctive splicing characteristics. This regulatory landscape underscores the central role of RNA-binding proteins in dinoflagellate biology. In this review, we summarize current knowledge on major RNA-binding protein groups identified or bioinformatically annotated in dinoflagellates, including RNA recognition motif domain-containing proteins, Sm and Sm-like family, KH domain-containing proteins, zinc-finger proteins, and Pumilio family proteins, S1 domain-containing and cold shock domain-containing proteins, DEAD/DEAH-box RNA helicases, and pentatricopeptide repeat proteins. We focus on the features of their conserved domains, their functions in eukaryotes, and available data on their presence and putative roles in dinoflagellate cells. Integrating genomic, transcriptomic, and proteomic evidence, and where possible experimental data, we highlight both their overall conservation and potential lineage-specific traits. Our aim is to provide a concise synthesis of current knowledge, identify key uncertainties, and outline promising directions for future research into the evolution and cellular roles of RNA-binding proteins in this ecologically and biologically remarkable group.