Evidence mapPaperPMID 41516357Full record

ReviewInternational journal of molecular sciences2026

Mitochondrial Health Through Nicotinamide Riboside and Berberine: Shared Pathways and Therapeutic Potential.

Federico Visalli, Matteo Capobianco, Francesco Cappellani, Lorenzo Rapisarda, Alfonso Spinello, Alessandro Avitabile, Ludovica Cannizzaro, Caterina Gagliano, Marco Zeppieri

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Mitochondrial Resilience in Glaucoma: Targeting NADDiseases (Basel, Switzerland) · 2026
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federico VisalliDepartment of Ophthalmology, University of Catania, 95123 Catania, Italy.ORCID 0009-0005-6710-2460
Matteo CapobiancoDepartment of Ophthalmology, University of Catania, 95123 Catania, Italy.ORCID 0009-0009-2969-8610
Francesco CappellaniDepartment of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.ORCID 0009-0007-6807-9455
Lorenzo RapisardaAzienda Sanitaria Provinciale 8 Siracusa, Presidio Ospedaliero Umberto I, 96100 Siracusa, Italy.
Alfonso SpinelloMediterranean Foundation "G.B. Morgagni", 95125 Catania, Italy.
Alessandro AvitabileFaculty of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0009-0003-1051-876X
Ludovica CannizzaroFaculty of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0009-0001-7556-6952
Caterina GaglianoDepartment of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.ORCID 0000-0001-8424-0068
Marco ZeppieriDepartment of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.ORCID 0000-0003-0999-5545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B

Indexed as

BerberineMitochondriaNiacinamideAnimalsHumansPyridinium CompoundsSignal TransductionBerberineNiacinamidenicotinamide-beta-ribosidePyridinium Compoundsberberinecardiometabolic diseasemitochondrial dysfunctionNAD+ metabolismneuroprotectionnicotinamidenicotinamide ribosideoxidative stressretinal ganglion cells

Identifiers

PMID41516357
PMCPMC12786874

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.