ArticleInternational journal of molecular sciences2026
Targeting Ferroptosis to Restore Salivary Gland Homeostasis in an Obesity Model.
Gi Cheol Park, Hanaro Park, Soo-Young Bang, Ji Min Kim, Sung-Chan Shin, Yong-Il Cheon, Ha-Nee Kwon, Jung Hwan Cho, Byung-Joo Lee
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Gi Cheol ParkDepartment of Otolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea.ORCID 0000-0001-7346-8550 Hanaro ParkDepartment of Otolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea.ORCID 0000-0001-6804-0760 Soo-Young BangDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea.
Ji Min KimDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea.
Sung-Chan ShinDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea.
Yong-Il CheonDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea.
Ha-Nee KwonDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea.ORCID 0000-0002-6965-9589 Jung Hwan ChoDivisions of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea.ORCID 0000-0001-8578-2117 Byung-Joo LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Good Gang-An Hospital, Busan 48265, Republic of Korea.
Funding
Korean government (MSIT) RS-2022-NR070216
6 · The paper itselfAbstract
Obesity is a systemic metabolic disorder that is known to impair various organ systems; however, its precise impact on salivary gland homeostasis remains unclear. Recent studies have implicated ferroptosis-an iron-dependent form of regulated cell death characterized by lipid peroxidation and oxidative stress-in glandular dysfunction. In this study, we used leptin-deficient (
Indexed as
CyclohexylaminesFerroptosisHomeostasisObesitySalivary GlandsAnimalsDeferoxamineDisease Models, AnimalIronLeptinLipid PeroxidationMaleMiceOxidative StressPhenylenediaminesReactive Oxygen SpeciesCyclohexylaminesDeferoxamineferrostatin-1IronLeptinPhenylenediaminesReactive Oxygen Speciesdeferoxamineferroptosisferrostatin-1mitochondrial dysfunctionobesitysalivary gland
Identifiers
PMID41516387
PMCPMC12786536
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