Zn-IMP 3D Coordination Polymers for Drug Delivery: Crystal Structure and Computational Studies.

Hafiz Zeshan Aqil, Yanhong Zhu, Masooma Hyder Khan, Yaqoot Khan, Beenish Sandhu, Muhammad Irfan, Hui Li

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Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Hafiz Zeshan AqilKey Laboratory of Cluster of Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Yanhong ZhuSchool of Pharmacy, North China University of Science and Technology, 21 Bohai Road, Caofeidian Xincheng, Tangshan 063210, China.ORCID 0009-0007-4072-6710

Masooma Hyder KhanKey Laboratory of Cluster of Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.ORCID 0009-0005-2074-938X

Yaqoot KhanKey Laboratory of Cluster of Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.ORCID 0009-0000-0294-8477

Beenish SandhuDepartment of Zoology, University of Sialkot, Sialkot 51040, Pakistan.

Muhammad IrfanKey Laboratory of Cluster of Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Hui LiKey Laboratory of Cluster of Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.ORCID 0000-0001-7459-6618

Funding

National Natural Science Foundation of China 21471017

6 · The paper itself

Abstract

Coordination polymers (CPs) are garnering attention in the field of medicine day by day. The goal is to develop a CP with biosafe and environment-friendly characteristics. Herein, we report two such novel 3D coordination polymers of zinc-inosine-5'-monophosphate (Zn-IMP) and bpe/azpy (as linkers) which were engineered as metal-organic frameworks that can be used as drug carriers for hydroxyurea (HU). We employed SCXRD, PXRD, solid-state CD, FTIR and TGA for crystal structure characterizations; the results achieved 3D coordination polymers which contain a

Indexed as

coordination polymershydroxyurea bindingpH-dependent molecular dynamicstargeted drug deliveryZn–IMP

Identifiers

PMID41516902

DOI10.3390/polym18010119

PMCPMC12787693

What Socratic holds

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