Evidence mapPaperPMID 41517646Full record

ReviewJournal of clinical medicine2026

Male Infertility: A Comprehensive Review of Urological Causes and Contemporary Management.

Biagio Barone, Ugo Amicuzi, Simone Tammaro, Michelangelo Olivetta, Marco Stizzo, Michele Musone, Luigi Napolitano, Luigi De Luca, Pasquale Reccia, Federico Capone and 16 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Ascorbic acid enhancesFrontiers in cell and developmental biology · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Biagio BaroneDepartment of Urology, P.O. San Paolo, ASL Napoli 1 Centro, 80145 Naples, Italy.ORCID 0000-0003-4884-132X
Ugo AmicuziDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Simone TammaroDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0009-0001-9000-7534
Michelangelo OlivettaUrology Unit, Department of Surgical Sciences, AORN Sant'Anna e San Sebastiano, 81100 Caserta, Italy.
Marco StizzoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Michele MusoneDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0009-0009-1529-982X
Luigi NapolitanoDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-2036-0356
Luigi De LucaDivision of Urology, Department of Surgical Multispecialty, AORN Antonio Cardarelli, 80131 Naples, Italy.
Pasquale RecciaUrology Unit, AORN Ospedali dei Colli, Monaldi Hospital, 80131 Naples, Italy.
Federico CaponeDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Arturo LecceDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Giovanni PaganoDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Silvestro ImperatoreDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Stefano ChianeseDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Salvatore PapiDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Giampiero Della RosaDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Fabrizio DinacciDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Mariano CoppolaDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Antonio MadonnaDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
Marco GrilloDepartment of Urology, P.O. San Paolo, ASL Napoli 1 Centro, 80145 Naples, Italy.
Dante Di DomenicoDepartment of Urology, P.O. San Paolo, ASL Napoli 1 Centro, 80145 Naples, Italy.
Francesco Del GiudiceDepartment of Urology, University Sapienza, 00185 Rome, Italy.ORCID 0000-0003-3865-5988
Vincenzo Francesco CaputoUnit of Urology, San Carlo Hospital, 85100 Potenza, Italy.
Dario Del BiondoDepartment of Urology, P.O. San Paolo, ASL Napoli 1 Centro, 80145 Naples, Italy.
Roberto FalabellaUnit of Urology, San Carlo Hospital, 85100 Potenza, Italy.
Felice CrocettoDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-4315-7660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility is a prevalent global health issue, with urological disorders representing some of the most common and correctable causes. Key conditions such as varicocele, obstructive azoospermia, erectile dysfunction and Peyronie's disease impair fertility through distinct pathophysiological mechanisms, including disrupted spermatogenesis, reproductive tract obstruction and failed sperm delivery. The effective management of these conditions hinges on a systematic diagnostic evaluation, which integrates clinical history, physical examination, semen analysis and specialized imaging. Modern management follows a logical progression, beginning with foundational lifestyle modifications, advancing to targeted medical or surgical interventions, and culminating, when necessary, in assisted reproductive technologies. Treatment strategies are therefore highly targeted, ranging from medical management and surgical correction-such as varicocelectomy or microsurgical reconstruction-to sperm retrieval techniques. Furthermore, evidence-based lifestyle modifications and a multidisciplinary clinical approach are fundamental to optimizing reproductive outcomes for affected couples. A comprehensive understanding of these urological etiologies is therefore essential for guiding appropriate intervention and improving the prospects of achieving pregnancy.

Indexed as

azoospermiaerectile dysfunctionlifestyle modificationsmale infertilityPeyronie’s diseasesperm retrievalurological causesvaricocele

Identifiers

PMID41517646
PMCPMC12787072

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.