Evidence map›Paper›PMID 41518007›Full record

ArticleStress (Amsterdam, Netherlands)2026

Development of a novel analysis method for evaluating PTSD-like behavior in mice based on DSM-V criteria.

Heather Holman, Kaylee Eggert, Ying Xiong, Paul J Nietert, Sara J Sidles, Ryan R Kelly, Amanda C LaRue, Patrick J Mulholland, Jennifer A Rinker, Jeffrey A Jones

Abstract read
In one paragraph

Article in Stress (Amsterdam, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heather HolmanDepartment of Surgery, Medical University of South Carolina, Charleston, SC, United States.
Kaylee EggertDepartment of Surgery, Medical University of South Carolina, Charleston, SC, United States.
Ying XiongDepartment of Surgery, Medical University of South Carolina, Charleston, SC, United States.
Paul J NietertDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
Sara J SidlesDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.
Ryan R KellyDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.
Amanda C LaRueDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.
Patrick J MulhollandDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.
Jennifer A RinkerDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.
Jeffrey A JonesDepartment of Surgery, Medical University of South Carolina, Charleston, SC, United States.ORCID 0000-0002-5133-0427

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
South Carolina Clinical & Translational Research Institute (SCTR)TL1TR001451 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FEGHALI-BOSTWICK, CAROL A. · 2015 to 2024
$4.6M
Stress-Induced Signaling in AortopathyF31HL172645 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Heather L. Holman · 2025 to 2026
$106k
BLRD VA I01 BX000904BLRD VA I01 BX005168BLRD VA I01 BX005870NCATS NIH HHS TL1 TR001451NCATS NIH HHS UL1 TR001450NHLBI NIH HHS F31 HL172645
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) occurs after exposure to a traumatic event, leading to debilitating symptoms, including avoidance, hypervigilance, and functional impairment. There is a paucity of effective therapies to treat PTSD, partially due to the difficulty in identifying consistent underlying mechanisms. Using a modified single prolonged stress (mSPS) paradigm combined with single housing to induce both acute fear conditioning and chronic stress in mice, we developed a novel analysis method to robustly define a PTSD-like phenotype based on the criteria from the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V). Following mSPS exposure, C57BL/6NHsd mice underwent behavioral testing to examine each of the criteria of PTSD according to the DSM-V. Specific parameters with the largest effect sizes between mSPS and non-mSPS mice were chosen. Absolute

Indexed as

Behavior, AnimalDiagnostic and Statistical Manual of Mental DisordersStress Disorders, Post-TraumaticAnimalsDisease Models, AnimalFearMaleMiceMice, Inbred C57BLPhenotypeStress, Psychologicalanalysis methodDSM-Vinescapable foot shockmodified single prolonged stressmouse behaviorPosttraumatic stress disorder

Identifiers

PMID41518007
PMCPMC13244265

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.