ArticleTransfusion2026
Longitudinal metabolomics study of phosphate-adenine-guanosine-glucose-saline-mannitol stored red blood cells.
Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sphingolipid metabolism and hematologic disorders: current understanding and future directions.Frontiers in physiology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion-related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage-induced metabolic change is crucial for enhancing transfusion safety. STUDY DESIGN AND
methodsWe conducted targeted metabolomic profiling of RBC supernatants stored in PAGGS-M over 42 days, collecting 161 weekly samples from 23 units. We analyzed 188 metabolites across six compound classes (hexoses, amino acids, biogenic amines, acylcarnitines, glycerophospholipids, and sphingolipids) along with 20 hematological parameters. Additionally, a mast cell degranulation assay evaluated the impact of these changes on ATR risk.
resultsOver 100 of the 188 metabolites changed significantly during storage, indicating diverse pathway alterations. Key findings include the accumulation of acylcarnitines and depletion of methionine, with mast cell degranulation significantly increased in supernatants from 42-day-old pRBCs versus fresh units. Notably, methionine depletion coincided with a critical transition phase in storage-associated metabolic aging. In addition, elevated levels of acylcarnitines correlated with increased markers of membrane damage, highlighting potential mechanisms underlying allergic transfusion reactions. DISCUSSION: This study highlights the impact of storage-induced metabolic changes in exacerbating transfusion-related complications. Therefore, optimization of additive solutions, such as stabilizing methionine levels during storage, may mitigate storage lesions and improve outcomes. Additionally, the storage-time-related increase in mast cell activation suggests a need for targeted interventions, particularly for patients vulnerable to ATRs.
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