Evidence map›Paper›PMID 41518282›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub-Quantal Exocytosis in Living Neurons and Organoids.

Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wanying Zhu *School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.ORCID 0000-0002-6292-4108
Yufan Zhang *School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Hanwen YuSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Da WangSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Xinyue ZhangSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Xiaowen DuSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Shanshan WuSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Bingzhi LiState Key Laboratory of Microbial Technology, Nanjing Normal University, Nanjing, 210023, China.
Yizhou ZhangSchool of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044, China.
Hongliang XinSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Xing GuoState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, 211166, China.
Yan LiuSchool of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.ORCID 0000-0003-2918-5398

Funding

National Key R&D Program of China 2021YFA1101800National Key R&D Program of China 2022YFA1104800National Natural Science Foundation of China 22274079National Natural Science Foundation of China 82171528National Natural Science Foundation of China 82325015National Natural Science Foundation of China 82371260National Natural Science Foundation of China 82530038National Natural Science Foundation of China 82574367National Natural Science Foundation of China U23A20429Natural Science Foundation of Jiangsu Province BK20240131Natural Science Foundation of Jiangsu Province BK20240520Natural Science Foundation of Jiangsu Province BK20250577Open Project Grant of the Key Laboratory of Clinical Neurology, Ministry of Education 2025A03
6 · The paper itself

Abstract

Acetylcholine (ACh) is a critical neurotransmitter that regulates diverse physiological functions, such as cognition and muscle contraction, through synaptic transmission. However, in situ quantitative chemical analysis of single-vesicle storage and release dynamics at single-cell level remains a major technical challenge, hindering mechanistic understanding of cholinergic synaptic plasticity across physiological and pathological states. To address this, we developed an Ti

Indexed as

AcetylcholineExocytosisNeuronsOrganoidsAnimalsHumansMiceAcetylcholineAcetylcholine (ACh)Human spinal cord organoidsPrimary cholinergic neuronsSub‐quantal releaseVesicular storage

Identifiers

PMID41518282
PMCPMC13159400

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.