Evidence map›Paper›PMID 41518388›Full record

SynthesisBreast cancer research and treatment2026

Updated systematic review and meta-analysis: taking the next step in physical activity behavioral interventions for post-treatment breast cancer survivors.

Brianna N Leitzelar, Alana R Willis, Sarah N Price, Janet A Tooze, Helena M VonVille, Rachel Lintz, Shirley M Bluethmann

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brianna N LeitzelarSchool of Kinesiology, University of Minnesota-Twin Cities, Minneapolis, MN, USA. leitz025@umn.edu.
Alana R WillisDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Sarah N PriceDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Janet A ToozeDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Helena M VonVilleHealth Sciences Library System, University of Pittsburgh, Pittsburgh, PA, USA.
Rachel LintzDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Shirley M BluethmannDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patientsR01CA262041 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jennifer Lynne Huberty, Ruben A. Mesa · 2022 to 2026
$2.8M
Cancer Prevention And Control Training Grant (CAPACITY)T32CA122061 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRISTIE L FOLEY, Kathryn Elizabeth Weaver · 2019 to 2026
$2.1M
Refining Cognitive Behavioral Therapy for Insomnia in Lung Cancer Survivors: Enhancing Feasibility, Acceptability, and Symptom ManagementK99CA297014 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Sarah Newmeyer Price · 2025 to 2026
$225k
NCI NIH HHS K99 CA297014NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA262041NCI NIH HHS T32 CA122061
6 · The paper itself

Abstract

purposeTo provide an updated review of the literature on physical activity (PA) intervention studies, their characteristics, and their effect size estimates for PA behavior change among early post-treatment breast cancer survivors (BCS).

methodsEligible studies were published between 2014-2025 in English, were quasi- or randomized controlled trials, studied BCS ≤ 5 years post-treatment, tested a PA intervention, and assessed PA behavior. We searched PubMed, APA PsycINFO, Embase, and CINAHL (latest search October 2025; CINAHL June 2020). Extracted data included study, participant, intervention, and outcome descriptors. The ROB 2 assessed risk of bias. A random effects model on post-intervention Cohen's d standardized mean differences (SMD) values meta-analysis was performed.

resultsTwenty-two RCTs with a total sample size of 2,390 (mean = 109, range = 26-692) were included. All included BCS were female, were on average 57 years old, and predominantly (> 60%) non-Hispanic White. Most study populations were mixed in terms of cancer stage and treatment type. Intervention duration ranged from 6-104 weeks. All studies except one were partially or fully home-based. All behavioral counseling interventions were theory-based. The overall SMD was d = 0.36 (95% confidence interval: 0.22, 0.50) in favor of the intervention. Two studies had some concerns for risk of bias; all others were rated as low.

conclusionThe present updated review found a small-to-moderate positive effect of PA interventions on PA behavior change among early post-treatment BCS. We note some shifts in the participant samples and study design since the originally published review. Practical implications for improving the reporting of future research include following established reporting guidelines to enhance reporting transparency, which would allow for more precise quantification of specific intervention effects and deeper contextual understanding of this body of work.

Indexed as

Behavior TherapyBreast NeoplasmsCancer SurvivorsExerciseFemaleHumansRandomized Controlled Trials as TopicBehavior changeBreast cancerCancer rehabilitationPhysical activitySurvivorship

Identifiers

PMID41518388
PMCPMC12790553

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.