ReviewApoptosis : an international journal on programmed cell death2026
Programmed cell death of keratinocytes: an active driver in psoriasis.
Review in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A systems-oriented Ayurvedic approach in chronic plaque psoriasis with renal inflammatory indicators: a 2-year longitudinal case report.Frontiers in medicine · 2026Article
- Neuroimmune regulation of post-traumatic bone regeneration: focus on inflammatory switching and functional recovery.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Psoriasis is a common, chronic inflammatory skin disorder with a high prevalence across all age groups, imposing a substantial burden on both individuals and society. It is characterized by epidermal hyperplasia and infiltration of immune cells into the dermis. Within the psoriatic microenvironment, epidermal keratinocytes contribute to a self-amplifying inflammatory response through the generation of "feed-forward" inflammation. Contrary to the earlier view of keratinocytes as passive "victims" in psoriasis pathogenesis, growing evidence supports their role as "active drivers" of disease progression. Programmed cell death (PCD) in keratinocytes interacts dynamically with immune cells, cytokines, damage-associated molecular patterns (DAMPs), and other factors, forming a complex regulatory network. Multiple PCD-related molecules in keratinocytes have been identified, many of which hold promise as biomarkers or therapeutic targets. These molecules may inform the development of new diagnostic and treatment strategies for psoriasis. This review outlines the major PCD pathways in keratinocytes-apoptosis, necroptosis, ferroptosis, and pyroptosis-and examines their roles in psoriasis. We also summarize recent therapeutic advances that modulate keratinocyte cell death and discuss how these pathways shape the cutaneous immune microenvironment.
Indexed as
Identifiers
41518404What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.