ReviewBrain structure & function2026
Exploring retinal microglia: development, degeneration, and iPSC-derived model systems.
Review in Brain structure & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Microglia are key regulators of retinal development, immune surveillance, and neuroprotection. Derived from yolk sac progenitors, they exhibit precise laminar distribution within the retina and fulfill diverse physiological roles, including synaptic pruning, phagocytosis, and modulation of inflammation and angiogenesis. In retinal diseases such as retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy, microglial activation contributes to neurodegeneration and pathological remodeling. This review summarizes recent advances in our understanding of retinal microglial ontogeny, distribution, and function, with particular emphasis on human pluripotent stem cell (hPSC)-derived microglia (iMG) .We highlight in vitro and chimeric iMG-based models that facilitate human-specific studies and discuss their emerging applications in retinal disease modeling, therapeutic screening, and personalized medicine.
Indexed as
Identifiers
41518430What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.