ReviewCurrent atherosclerosis reports2026
Pleiotropic Effects of Statins: Focus on Inflammation, Oxidative Stress and Immunomodulation (Part I).
Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological effects of statins in systemic sclerosis: a systematic review and meta-analysis of 323 patients.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Pooled it
- Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects.Endocrinology, diabetes & metabolism · 2026Review
- The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021-2025 State-of-the-Art Review of Clinical and Preclinical Evidence.Pharmacology research & perspectives · 2026Review
- Decoding the Role of Lipid Metabolism and Membrane Dynamics in Melanoma.International journal of molecular sciences · 2026Review
- Association of pre-admission statin use with clinical outcomes in aneurysmal subarachnoid hemorrhage: a multicenter, observational, real-world study.Frontiers in neurology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewStatins are the most widely prescribed class of drugs for cardiovascular (CV) disease (CVD) prevention due to their potent lipid-lowering effects. However, accumulating evidence demonstrates additional cardioprotective properties of statins mediated through pleiotropic mechanisms unrelated to cholesterol modulation. We aimed to discuss the pleiotropic effects of statins and their relevance to clinical outcomes in 2 reviews: Part I focuses on anti-inflammatory, antioxidant and immunomodulatory effects of statins, whereas Part II on statin-induced endothelial function improvement, plaque stabilization and anti-thrombotic effects. Part II also includes a clinical applications and future directions section. RECENT
findingsA literature search was conducted in Embase, Scopus, web of science, PubMed and Cochrane Library databases for experimental and clinical studies investigating the effects of statins on inflammation, oxidative stress and immune function. Statins exert potent anti-inflammatory, antioxidant and immunomodulatory activities that can be linked to reduced CV events. Statins confer cardio protection via diverse pleiotropic pathways distinct from cholesterol modulation. Future directions involve optimizing regimens to maximize clinical benefits, addressing controversies, and exploring statins' therapeutic potential beyond CVD through non-lipid mechanisms. A comprehensive understanding of statins' pleiotropic profile will uncover new preventive strategies and therapeutic applications.
Indexed as
Identifiers
41518479What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.