Evidence map›Paper›PMID 41518525›Full record

ReviewApoptosis : an international journal on programmed cell death2026

The emerging role of cholesterol metabolism in gynecologic cancer development and therapy.

Hejing Liu, Yujia Zhou, Jiamin Zhang, Liqing Miao, Qianqian Wu, He Zhu, Shuya Pan, Xueqiong Zhu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hejing Liu *Zhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Yujia Zhou *Zhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Jiamin ZhangZhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Liqing MiaoZhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Qianqian WuZhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
He ZhuZhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Shuya PanZhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China.
Xueqiong ZhuZhejiang Provincial Clinical Research Center for Gynecological Diseases, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No.109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, People's Republic of China. zjwzzxq@163.com.

Funding

Natural Science Foundation of Zhejiang Province LMS25H160024Zhejiang Key Laboratory of Traditional Chinese Medicine for Diagnosis and Treatment of Gynecological Cancers 2022-11
6 · The paper itself

Abstract

The significance of cholesterol metabolism in cancer is a topic of renewed interest. Cholesterol is an essential factor for mammal cells, for it is not only involved in constituting the cell membrane, but also serves as a precursor to steroid hormones and bile acids. Numerous studies have provided increasing evidence of its high relevance to cancer progression. Targeting cholesterol metabolism by using cholesterol metabolism inhibitors has offered another therapeutic strategy for reversing drug resistance in tumors. Here, the regulatory process of cholesterol homeostasis under normal physiological conditions was introduced. Then, the mechanism by which cholesterol metabolism disorder caused gynecologic cancer development and therapy resistance was summarized. Finally, the therapeutic strategies targeting cholesterol metabolism were also discussed in this review.

Indexed as

CholesterolGenital Neoplasms, FemaleAnimalsAntineoplastic AgentsDrug Resistance, NeoplasmFemaleHumansLipid MetabolismAntineoplastic AgentsCholesterolCholesterol metabolismGynecological cancerTherapeutic strategyTherapy resistanceTumorigenesis

Identifiers

PMID41518525
PMCPMC12790502

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.