ArticleBioprocess and biosystems engineering2026
Boosting biomass and superoxide dismutase yield in Tetraselmis chuii via two-stage cultivation and adaptive laboratory evolution.
Article in Bioprocess and biosystems engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Microalgae, such as Tetraselmis chuii, are potent sources of natural antioxidants, attributed to their adaptation to oxidative stress in harsh marine environments. This study aimed to investigate superoxide dismutase (SOD) production in T. chuii, a microalga recently approved as a novel food by the European Union. Although oxidative stress application was hypothesized to enhance SOD biosynthesis, direct stress exposure potentially compromises biomass accumulation, creating a trade-off between cell density and antioxidant production. Therefore, a two-stage cultivation strategy was employed: the first stage focused on optimizing biomass through medium enhancement until an adequate cell density was achieved in the stationary phase, followed by the controlled induction of oxidative stress to stimulate SOD overproduction without significantly impacting the established biomass. F medium, supplemented with NH₄Cl, was selected as the basal cultivation medium. Key components, such as NH
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