Evidence map›Paper›PMID 41518559›Full record

ReviewPlant foods for human nutrition (Dordrecht, Netherlands)2026

Phytochemical, Nutritional and Medicinal Properties of Manihot esculenta Leaves: An Integrated Review of Nutritional and Anticancer Insights.

Mohammad Shahbaaz Ahmed, Afsheen Fatima, Khursheed Ahmad, Shivbrat Upadhyay, Rumana Ahmad, Aditi Srivastava, Mohsin Ali Khan, Manaal Zahera, Afsana Khatoon, Mohammad Azhar Kamal and 2 more

Abstract readReview
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In one paragraph

Review in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohammad Shahbaaz AhmedDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Afsheen FatimaDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Khursheed AhmadDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Shivbrat UpadhyayDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Rumana AhmadDepartment of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Aditi SrivastavaDepartment of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Mohsin Ali KhanResearch and Development Unit, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
Manaal ZaheraDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India.
Afsana KhatoonDepartment of Arab Culture, Karamat Husain Muslim Girls' P.G. College, University of Lucknow, Lucknow, India.
Mohammad Azhar KamalDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, 11942, Saudi Arabia.
Shaheenkousar H HattiwaleDepartment of Basic Medical Sciences, College of Medicine, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Sahabjada SiddiquiDepartment of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, 226003, India. sahabjadabiotech04@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products have acquired prominence in scientific study and medicine owing to their increasing significance in the treatment of human ailments. Manihot esculenta Crantz (cassava) is a fundamental agricultural food crop, widely utilized for its starchy tubers. Cassava leaves are rich in essential components such as calcium, iron, protein, and vitamins A, B, C and K. The leaves have several secondary metabolites, including alkaloids, tannins, and flavonoids, which exhibit anti-inflammatory, antibacterial, anti-diabetic, and immune-modulatory properties. These secondary metabolites may safeguard cells against oxidative stress, chronic diseases, viral ailments, cardiovascular conditions, and specific cancer kinds. These bioactive compounds play a vital role in mitigating oxidative stress, chronic inflammation, and immune dysregulation-key factors implicated in cancer initiation and progression-thus warranting comprehensive investigation of cassava leaves within this framework. Despite their rich phytochemical composition, the nutritional and medicinal significance of cassava leaves remains underexplored. This review aims to summarize the phytochemical constituents of cassava leaves and elucidate their potential health-promoting translational values and anticancer properties. By integrating in vitro, in vivo, and clinical evidence, the review highlights the molecular mechanisms of cassava leaf phytochemicals underlying their anticancer effects and discusses translational implications, existing research gaps, and future directions for experimental and clinical studies.

Indexed as

Antineoplastic Agents, PhytogenicManihotPhytochemicalsPlant LeavesAlkaloidsAnti-Inflammatory AgentsAntioxidantsFlavonoidsHumansNeoplasmsNutritive ValuePlant ExtractsTanninsAlkaloidsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntioxidantsFlavonoidsPhytochemicalsPlant ExtractsTanninsAnticancerManihot esculenta crantzNutraceuticalsPharmacological characteristicsPhytochemistry

Identifiers

PMID41518559

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.