Evidence map›Paper›PMID 41518591›Full record

Trial reportJournal of the American Geriatrics Society2026

Perceived Pain Following Hypnotic Deprescribing in Older Adults.

Jennifer G Hurtado, Alexander J Erickson, Michael N Mitchell, Jennifer L Martin, Cathy A Alessi, Joseph M Dzierzewski, Sara Ghadimi, Erin Der-Mcleod, Claudia Perdomo, Saadia Naeem and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jennifer G HurtadoKirk Kerkorian School of Medicine at UNLV, Las Vegas, Nevada, USA.
Alexander J EricksonVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.ORCID 0000-0002-1025-427X
Michael N MitchellVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.
Jennifer L MartinVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.
Cathy A AlessiVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.
Joseph M DzierzewskiNational Sleep Foundation, Washington, DC, USA.
Sara GhadimiVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.
Erin Der-McleodVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.
Claudia PerdomoDepartment of Medicine, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Saadia NaeemVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.
Alison A MooreUniversity of California San Diego (UCSD), La Jolla, California, USA.
M Safwan BadrWayne State University & John D. Dingell VA Health Care System, Detroit, Michigan, USA.
Michelle ZeidlerDepartment of Medicine, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Constance H FungVA Greater Los Angeles Geriatric Research, Education and Clinical Center, Los Angeles, California, USA.

Funding

A Novel Mechanism for Helping Older Adults Discontinue Use of Sleeping PillsR01AG057929 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FUNG, CONSTANCE · 2018 to 2022
$2.7M
Sleep health in special populationsK24HL143055 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, JENNIFER L · 2018 to 2025
$898k
Clinical and Translational Science Institute, University of California, Los Angeles NCATSUL1TR001881Daniel F & Z Drescher Kripke Revocable TrustDepartment of Veterans Affairs Geriatric Research Education and Clinical CenterDepartment of Veterans Affairs Health Systems Research HSRIIR17-234Department of Veterans Affairs Health Systems Research RCS20-191NHLBI NIH HHS K24 HL143055NHLBI NIH HHS K24HL143055NIA NIH HHS R01AG057929Stein Institute for Research on Aging, University of California San DiegoUCLA Medical Student Training in Aging Research Program NIAT35AG026736
6 · The paper itself

Abstract

backgroundOlder adults with chronic insomnia often use benzodiazepine receptor agonists (BZRAs) despite known associated risks and non-pharmacological alternatives such as cognitive behavioral therapy for insomnia (CBTI). CBTI reduces insomnia severity and could potentially improve other outcomes such as the impact of pain on daily activities, even when BZRAs are deprescribed. Yet concerns that deprescribing may worsen pain (which is often comorbid with insomnia) can be a barrier to engagement in BZRA deprescribing. This study examined changes in pain outcomes associated with deprescribing BZRAs in the context of concurrent CBTI.

methodsSecondary data analysis was conducted using data from a randomized clinical trial that successfully decreased BZRA use in older adults. Participants (n = 188), who were largely older (68% ≥ 65 years, 55 ≤ range ≤ 91) and male (65%), completed CBTI concurrently with a deprescribing intervention (blinded encapsulated BZRA taper or open pill cutter taper). Participants completed the Brief Pain Inventory (BPI) at baseline, one week posttreatment (1 WK), and at a six-month (6 M) follow-up. Analyses included mixed effects models among all participants and a subset aged 65+ as well as comparison of model results to minimal clinically important difference (MCID) thresholds.

resultsMixed effects models demonstrated that pain severity did not change significantly over time, broadly or in participants aged ≥ 65 years. Significant reductions in pain interference in day-to-day living at 1 WK were observed broadly, although these reductions did not meet the MCID threshold and were no longer significant at 6 M follow-up.

conclusionsCombined BZRA deprescribing and CBTI did not meaningfully worsen pain in older adults. These results highlight the opportunity for using a combination of CBTI and deprescribing methods in patients with insomnia and comorbid pain, as well as a need for additional interventions to specifically address pain in older adults with chronic insomnia.

Indexed as

Cognitive Behavioral TherapyDeprescriptionsGABA-A Receptor AgonistsHypnotics and SedativesPainPain PerceptionSleep Initiation and Maintenance DisordersAgedAged, 80 and overFemaleHumansMaleMiddle AgedPain MeasurementGABA-A Receptor AgonistsHypnotics and Sedativesbenzodiazepinesinsomniapain

Identifiers

PMID41518591
PMCPMC12968350

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.