ArticleNeuroendocrinology2026
Direct Intra-Accumbens 17 Beta-Estradiol Administration Increases Voluntary Wheel Running in Ovariectomized Rats.
Article in Neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionMetabolic dysfunction and the associated diseases (e.g., diabetes) are globally on the rise, and a sedentary lifestyle directly contributes to this issue. In fact, postmenopausal women are at increased risk for obesity and metabolic disease due to the loss of metabolically protective 17β-estradiol (E2). Exercise is vital for overall health, greatly reducing disease risk, but the central brain regions involved in drive for physical activity remain unclear.
methodsFemale Sprague-Dawley rats were ovariectomized (OVX) and concurrently bilaterally implanted with cannulae targeting the nucleus accumbens brain region, traditionally associated with reward and addiction. Daily voluntary wheel running (VWR) was tracked before and after OVX. One month after surgery, rats were treated with intra-accumbens microinjections (0.5 μL total volume) of one of three doses of E2: 0.6 μg/μL (low), 1.5 μg/μL (moderate), or 10 μg/μL (high).
resultsDaily VWR was significantly increased by intra-accumbens E2 microinjections in a non-rapid manner that persisted 48 h following microinjections.
conclusionFindings demonstrate for the first time that intra-accumbens E2 partially rescues OVX-induced decreases in daily wheel running.
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