SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells.

Mousumi Patra, Ratan Sadhukhan, Eva Allen, Faraz Kalantari, Heba Allam, Fen Xia

Abstract read

In one paragraph

Article in Cancer letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mousumi PatraDepartment of Radiation Oncology, Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Ratan SadhukhanDepartment of Radiation Oncology, Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Eva AllenDepartment of Radiation Oncology, Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Faraz KalantariDepartment of Radiation Oncology, Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Heba AllamDepartment of Radiation Oncology, Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Fen XiaDepartment of Radiation Oncology, Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. Electronic address: fxia@uams.edu.

Funding

The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repairR01CA247947 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI XIA, FEN · 2020 to 2025

$1.8M

NCI NIH HHS R01 CA247947

6 · The paper itself

Abstract

Radiation-induced oral mucositis (RIOM) is a common and debilitating toxicity of radiotherapy for head and neck squamous cell carcinoma (HNSCC), often compromising treatment adherence and profoundly impairing patient quality of life. Despite its significant clinical impact, there are currently no safe and well-tolerated FDA-approved therapies to prevent or treat RIOM. The underlying mechanisms remain poorly understood but are thought to involve inflammatory responses triggered by oxidative stress and DNA damage from ionizing radiation (IR). Here, we identify SIRT2, an NAD

Indexed as

DNA Breaks, Double-StrandedRadiation InjuriesSirtuin 2Stem CellsStomatitisAnimalsDNA RepairEpithelial CellsHead and Neck NeoplasmsHomologous RecombinationHumansMaleMiceMouth MucosaNADNiacinamideNADNiacinamideSIRT2 protein, humanSirt2 protein, mouseSirtuin 2DNA repairEpithelial stem cellNicotinamide ribosideRadiation-induced oral mucositisSIRT2

Identifiers

PMID41519461

DOI10.1016/j.canlet.2026.218239

PMCPMC12917874

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.