ArticleCommunications medicine2026
Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging.Communications medicine · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundChronological age does not capture individual health or resilience. Advances in metabolomics have enabled development of molecular aging biomarkers that capture deviations between biological and chronological age, highlighting how genetics, environment, and lifestyle shape biological aging. Despite their promise, metabolomic biomarkers face challenges such as interpretability, non-linearity, and reproducibility.
methodsWe have developed a metabolomic predictor of biological age based on untargeted metabolomic profiling of individuals aged 45-85 years from the Canadian Longitudinal Study on Aging. To enhance interpretability, we first identified metabolites related to health based on variance heterogeneity. For metabolites with identifiable optimal levels, or "sweet spots", we modeled non-linearity using deviations from these values. A penalized regression model was trained on the Frailty Index using sweet spot deviations as predictors.
resultsHere we show that the Sweet Spot Clock built on 178 health-related metabolites is strongly associated with all-cause mortality (HR = 1.08, p = 5.8×10
conclusionsThe Sweet Spot Clock provides a reproducible and interpretable measure of biological age. By modeling deviations from optimal metabolite levels and training on health status rather than age, it offers a tool for understanding aging heterogeneity and identifying individuals at risk of health decline.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.