Evidence map›Paper›PMID 41520293›Full record

ArticleBioinformatics (Oxford, England)2026

Malaria-GENOMAP: a web-based tool for exploring genomic variation of malaria parasites.

Joseph Thorpe, Nina Billows, Gabrielle C Ngwana-Joseph, Amy Ibrahim, Deborah Nolder, Colin J Sutherland, Thi Hong Ngoc Nguyen, Thi Huong Binh Nguyen, Quang Thieu Nguyen, Jamille G Dombrowski and 7 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Joseph ThorpeFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.ORCID 0009-0006-5860-0182
Nina BillowsFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.ORCID 0000-0002-3786-6911
Gabrielle C Ngwana-JosephFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
Amy IbrahimFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
Deborah NolderFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
Colin J SutherlandFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.ORCID 0000-0003-1592-6407
Thi Hong Ngoc NguyenMolecular Biology Department, Parasitology and Entomology, Vietnam National Institute of Malariology, Hanoi, 100000, Vietnam.
Thi Huong Binh NguyenMolecular Biology Department, Parasitology and Entomology, Vietnam National Institute of Malariology, Hanoi, 100000, Vietnam.
Quang Thieu NguyenMolecular Biology Department, Parasitology and Entomology, Vietnam National Institute of Malariology, Hanoi, 100000, Vietnam.
Jamille G DombrowskiDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu P , São Paulo, 05508-000, Brazil.
Silvia Maria Di SantiDepartment of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455 - Cerqueira César, São Paulo, 01246-903, Brazil.
Claudio R F MarinhoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu P , São Paulo, 05508-000, Brazil.
Jody E PhelanFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.ORCID 0000-0001-8323-7019
Tomasz KurowskiSchool of Water, Energy and Environment, Applied Bioinformatics, Cranfield University, Bedford, MK43 0AL, United Kingdom.
Fady MoharebSchool of Water, Energy and Environment, Applied Bioinformatics, Cranfield University, Bedford, MK43 0AL, United Kingdom.ORCID 0000-0002-7880-2519
Susana CampinoFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.ORCID 0000-0003-1403-6138
Taane G ClarkFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.ORCID 0000-0001-8985-9265

Funding

BBSRC LIDo PhD studentship BB/T008709/1EPSRC EP/Y018842/1UKRI MRC IAA2129UKRI MRC MR/R026297/1UKRI MRC MR/X005895/1
6 · The paper itself

Abstract

motivationMalaria, caused by Plasmodium parasites, imposes a significant public health burden. While Plasmodium falciparum remains the primary target of elimination strategies due to its high mortality rate, lesser-known species such as P. malariae, P. vivax, and P. knowlesi continue to contribute to substantial human morbidity. Genomic approaches, including whole-genome sequencing, offer powerful tools for understanding the biology, transmission, and emerging drug resistance of these neglected Plasmodium species. However, there is an urgent need for informatic tools to summarize and visualize the high-dimensional and complex genomic data generated.

resultsWe developed Malaria-GENOMAP, a user-friendly web-based tool, which integrates genomic variant data, such as allele frequencies, with geographical maps and chromosome-wide to gene views for in-depth exploration. The tool includes variation from P. knowlesi (n = 139), P. malariae (n = 158), P. ovale curtisi (n = 36), P. ovale wallikeri (n = 47), P. simium (n = 38), and P. vivax (n = 1359). It enables the investigation of population structure, geographic associations of mutations, and putative drug resistance markers, offering valuable insights for malaria control efforts. AVAILABILITY AND IMPLEMENTATION: Malaria-GENOMAP is available online at https://genomics.lshtm.ac.uk/malaria-genomaps.

Indexed as

Genetic VariationGenome, ProtozoanGenomicsMalariaPlasmodiumSoftwareHumansInternet

Identifiers

PMID41520293
PMCPMC12881832

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.