Evidence map›Paper›PMID 41520320›Full record

ArticleEJNMMI radiopharmacy and chemistry2026

Fluorine-18-labeled PET radiotracers for imaging the macrophage colony-stimulating factor 1 receptor (CSF1R).

Deepankar Das, Hyojin Cha, Ravi Naik, Daniel P Holt, Hong Fan, Andrew Hall, Wojciech G Lesniak, Yong Du, Il Minn, Robert F Dannals and 2 more

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In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Deepankar Das *Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Hyojin Cha *Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Ravi NaikDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Daniel P HoltDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Hong FanDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Andrew HallDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Wojciech G LesniakDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
Yong DuDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Il MinnDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
Robert F DannalsDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Martin G PomperDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA. Martin.Pomper@UTSouthwestern.edu.
Andrew G HortiDepartment of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA. ahorti1@jhmi.edu.ORCID http://orcid.org/0000-0003-2290-488X

Funding

F-18 labelled PET tracer for imaging macrophage colony stimulating factor 1 receptor (CSF1R) in neuroinflammationR01AG066464 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G · 2020 to 2022
$1.8M
NIA NIH HHS AG066464NIA NIH HHS R01 AG066464
6 · The paper itself

Abstract

backgroundPositron emission tomography is a useful tool for quantitative imaging of neuroinflammation in human subjects; however, more suitable radiotracers are sought. One of the promising targets for imaging neuroinflammation is macrophage colony-stimulating factor 1 receptor (CSF1R) because of its expression on activated microglia. Several PET radiotracers for imaging CSF1R have been developed, however, a suitable CSF1R radiotracer radiolabeled with

resultsA new series of CSF1R ligands with nanomolar binding affinities and structural properties suitable for brain PET was synthesized. Five compounds of the series were radiolabeled with

conclusionsA series of new PET radiotracers for imaging CSF1R was synthesized and tested in vitro and in animals. One member of the series, 2-[

Indexed as

CSF1RMicrogliaNeuroinflammationPositron emission tomographyTyrosine kinase

Identifiers

PMID41520320
PMCPMC12881222

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.