Evidence map›Paper›PMID 41520843›Full record

ArticleJournal of affective disorders2026

Inhibitory control-related neural pathways of early adversity to internalizing problems in preadolescence.

Krupali R Patel, Brianna N Hernandez, Alyssa J Parker, Lea R Dougherty, Jillian Lee Wiggins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Krupali R PatelDepartment of Psychology, San Diego State University, San Diego, California, United States. Electronic address: krpatel@sdsu.edu.
Brianna N HernandezDepartment of Psychology, San Diego State University, San Diego, California, United States.
Alyssa J ParkerDepartment of Psychology, University of Maryland, College Park, College Park, MD, United States.
Lea R DoughertyDepartment of Psychology, University of Maryland, College Park, College Park, MD, United States.
Jillian Lee WigginsDepartment of Psychology, San Diego State University, San Diego, California, United States; Joint Doctoral Program in Clinical Psychology, San Diego State University, University of California, San Diego, San Diego, California, United States.

Funding

Neural mechanisms of risk and resilience in early childhood irritability (Diversity Supplement - E. Peterson)R01MH121385 · NIMH · SAN DIEGO STATE UNIVERSITY · PI DOUGHERTY, LEA R, WIGGINS, JILLIAN LEE · 2020 to 2024
$3.7M
Neural mechanisms of risk for irritability across the transition to adolescenceR01MH122487 · NIMH · SAN DIEGO STATE UNIVERSITY · PI DOUGHERTY, LEA R, WIGGINS, JILLIAN LEE · 2021 to 2025
$1.8M
NIMH NIH HHS R01 MH121385NIMH NIH HHS R01 MH122487
6 · The paper itself

Abstract

objectiveExposure to early life adversity has long-reaching effects on the psychopathology of adolescents. However, some individuals exposed to early life stressors, such as threat and deprivation, do not later present with symptoms. Previous research suggests that neural mechanisms may play a role in differentiating pathways from early life threat or deprivation to internalizing symptoms.

methodThis study utilizes neuroimaging to examine the relationship between early adversity experiences and internalizing symptoms later on. Data from the ABCD® study were used to investigate whether inhibitory control-related neural functioning in the anterior cingulate cortex (ACC), superior frontal gyrus (SFG), and inferior frontal gyrus (IFG) moderated the relationship between threat or deprivation exposure and internalizing symptoms two years later (N = 4881; ages 9-10 years old at baseline).

resultsComposite scores of cumulative threat or deprivation-related exposures positively correlated with internalizing symptoms at 24 months following baseline. At high levels of ACC and left SFG activation during successful inhibition, the relationship between threat exposure and internalizing symptoms was attenuated. The association between deprivation and internalizing symptoms was greater for those with high levels of left SFG activation to successful inhibition. Activation in the IFG did not impact this association.

conclusionsThis difference underscores the importance of taking a brain-based, dimensional approach to early-life. Since the role of neural functioning differs based on the type of early life adversity and brain region, further investigation into other neural pathways that may influence the development of psychopathology following early life adversity is needed.

Indexed as

Adverse Childhood ExperiencesGyrus CinguliInhibition, PsychologicalNeural PathwaysPrefrontal CortexChildFemaleHumansMagnetic Resonance ImagingMaleEarly adversityInhibitory controlInternalizing symptomsProtective factors

Identifiers

PMID41520843
PMCPMC13204466

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.