Trial reportJournal of diabetes2026
Effects of Short-Term Intensive Insulin Therapy Combined With Oral Hypoglycemic Agents for Inducing Remission in Newly Diagnosed Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
Trial report in Journal of diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
aimsTo investigate the effects of combining oral hypoglycemic agents with short-term intensive insulin therapy (SIIT) via continuous subcutaneous insulin infusion (CSII) on glycemic outcomes in adults with newly diagnosed type 2 diabetes mellitus. MATERIALS AND
methodsIn this multicenter, open-label trial, 245 participants were randomized to three treatment arms: SIIT for 2 weeks (CSII group), SIIT plus 90-day metformin and pioglitazone (CSII + Met + Pio group), or SIIT plus 90-day sitagliptin (CSII + Sita group). The primary outcome was the 12-month diabetes remission rate. Parameters of glycemic control, β-cell function, and insulin resistance were compared among groups.
resultsThe participants had a mean HbA1c of 10.6% ± 2.2%. Compared to the CSII group, both combination groups had lower total daily and pre-meal bolus insulin requirements with higher time in tight target range (TITR) during SIIT, and had significantly greater acute insulin response (AIR) after SIIT. Three months post SIIT, more participants in the CSII + Met + Pio group (78.7%, 59/75) achieved HbA1c < 6.5% compared with the CSII group (59.0%, 46/78; adjusted p < 0.05), but the 12-month diabetes remission rates were similar (p = 0.972).
conclusionsOral hypoglycemic agents facilitated SIIT implementation and enhanced transient improvements in glycemic control. However, similar 12-month diabetes remission rates suggest prolonged sequential therapy may be needed for sustained glycemic benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.