Evidence map›Paper›PMID 41522191›Full record

ArticleNutrition and metabolic insights2026

Circulating Branched-Chain Amino Acids are Associated with Higher Odds of Obesity: Findings from the FiLWHEL Study.

Akinkunmi Paul Okekunle, Heejin Lee, Sherlyn Mae P Provido, Grace H Chung, Sangmo Hong, Sung Hoon Yu, Chang Beom Lee, Jung Eun Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and metabolic insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akinkunmi Paul OkekunleDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Korea.ORCID https://orcid.org/0000-0003-4825-4934
Heejin LeeDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sherlyn Mae P ProvidoDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Korea.
Grace H ChungDepartment of Child Development & Family Studies, Seoul National University, Korea.
Sangmo HongDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Sung Hoon YuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Chang Beom LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Jung Eun LeeDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Korea.ORCID https://orcid.org/0000-0003-1141-878X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dietary and circulating branched-chain amino acids (BCAA) exhibited divergent associations with obesity, and this study evaluated the independent and joint associations of dietary intakes and circulating concentrations of BCAA with obesity. Methods: Energy-adjusted dietary and log-transformed circulating BCAAs from 540 Filipino women were categorized into quartiles and dichotomized by the median, low(<median) or high(≥median) to examine the joint association as follows: "low dietary and low circulating"BCAA, "low dietary and high circulating"BCAA, "high dietary and low circulating" BCAA and "high dietary and high circulating"BCAA. Multivariable-adjusted logistic regression was used to compute the odds ratio(OR) and 95% confidence intervals(CI) of obesity(BMI ≥25kg/m Results: The odds of being obese by increasing quartile of dietary total BCAA were 1.00, 0.84 (0.49, 1.43), 0.68 (0.39, 1.19), and 0.56 (0.31, 1.02; Conclusion: Higher circulating BCAA profiles, independent of dietary BCAA intake levels, were associated with a higher prevalence of obesity, with no evidence of interaction in the divergent independent associations between dietary and circulating BCAAs and obesity.

Indexed as

body mass indexbranched-chain amino acidsdietmetabolomicswaist circumference

Identifiers

PMID41522191
PMCPMC12779912

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.