Evidence map›Paper›PMID 41522237›Full record

Reviewnpj biomedical innovations2026

Progress and challenges in transplantation of human pluripotent stem cell derived cardiomyocytes for cardiac therapy.

Jacelyn D Bain, Ryan W Barrs, Ying Mei

Abstract readReview
In one paragraph

Review in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacelyn D BainBioengineering Department, Clemson University, Clemson, SC USA.
Ryan W BarrsBioengineering Department, Clemson University, Clemson, SC USA.
Ying MeiBioengineering Department, Clemson University, Clemson, SC USA.

Funding

Nanowired hypoimmunogenic hPSC cardiac organoids for heart repairR01HL175050 · NHLBI · CLEMSON UNIVERSITY · PI XIAOJUN LIAN, Ying Mei · 2024 to 2026
$2.0M
Nanowired human cardiac spheroids for heart repairR01HL133308 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2017 to 2020
$1.5M
Nanowired humam cardiac organoid derived exosomes for heart repairR01HL168255 · NHLBI · CLEMSON UNIVERSITY · PI Ying Mei · 2023 to 2026
$1.5M
Nanowired human isogenic cardiac organoids to treat acute myocardial ischemia/reperfusion injuriesU01HL169361 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2023 to 2024
$746k
Human organoid model for COVID-19 myocarditisR21HL167211 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2023 to 2024
$411k
NHLBI NIH HHS R01 HL133308NHLBI NIH HHS R01 HL168255NHLBI NIH HHS R01 HL175050NHLBI NIH HHS R21 HL167211NHLBI NIH HHS U01 HL169361
6 · The paper itself

Abstract

Myocardial infarction and heart failure remain leading causes of mortality worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent a promising approach to regenerating damaged myocardium and restoring cardiac function. This review highlights advancements in hPSC-CM differentiation, scale-up, and clinical-grade manufacturing; delivery approaches; and insights from preclinical and clinical studies. We also examine mechanisms of repair, key challenges and mitigation strategies, and future directions to advance hPSC-CM therapies toward clinical translation.

Indexed as

Heart failurePreclinical researchRegenerative medicineStem-cell biotechnologyTissue engineeringTranslational research

Identifiers

PMID41522237
PMCPMC12779562

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.