ArticleTherapeutic advances in neurological disorders2026
Comprehensive versus thrombectomy-capable stroke centers: a web-based model to predict outcomes after mechanical thrombectomy.
Article in Therapeutic advances in neurological disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- New frontiers in acute reperfusion therapy for ischaemic stroke: from recanalisation to selection, delivery and safety.Therapeutic advances in neurological disorders · 2026Article
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18 authors.
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Abstract
Background: The quality and clinical outcomes of mechanical thrombectomy (MT) performed at thrombectomy-capable stroke centers (TSCs) versus comprehensive stroke centers (CSCs) remain insufficiently characterized. Objective: To compare MT outcomes between TSCs and CSCs and to develop and externally validate an online tool for individualized prognosis and decision support. Design: Retrospective cohort study including derivation and external validation cohorts from multiple stroke centers. Method: Patients with anterior circulation large vessel occlusion who underwent MT within 24 h were analyzed. Inverse probability of treatment weighting (IPTW) and multivariable logistic regression estimated the effects of stroke center certification. Sensitivity analyses using alternative model specifications, patient subsets, and predefined subgroups assessed robustness and heterogeneity. A prognostic model was developed using least absolute shrinkage and selection operator regression after IPTW, externally validated using 2023-2024 data from different centers, and deployed as a Shiny-based online tool predicting 90-day modified Rankin Scale outcomes (0-2 for independence, 0-5 for survival). Results: The median age was 69 years (interquartile range (IQR) 60-77) in the derivation cohort ( Conclusion: CSCs were significantly associated with a higher probability of survival compared to TSCs, while no significant difference was observed in favorable functional outcomes. An online multivariable model could predict clinical outcomes and guide decision-making between TSCs and CSCs in routine clinical practice.
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