Evidence map›Paper›PMID 41522338›Full record

ReviewInternational journal of biological sciences2026

Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders.

Li Xu, Chen Shen, Xin Liu, Yi Qin, Zebin Wu, Ziyu Zhang, Qifeng Sheng, Qihan Wang, Feng Zhou, Gaoran Ge and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Lactate-Mediated Lysine Lactylation in Renal Fibrosis: Current Progress and Challenges.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Li XuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Chen ShenDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Xin LiuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Yi QinDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Zebin WuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Ziyu ZhangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Qifeng ShengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Qihan WangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Feng ZhouDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Gaoran GeDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.
Dechun GengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Shizi Street, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocyte-macrophage plays a central role in innate immunity, tissue homeostasis maintenance, and disease progression. These phagocytes, which originate from blood monocytes or embryonic sources, are imperative for inflammatory responses, tissue repair, and bone remodeling. In orthopedic diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, and fractures, changes in histone acetylation are key to regulating macrophage gene expression, polarization, differentiation into osteoclasts, and pathological bone remodeling. Histone acetylation (mediated by histone acetylases) and deacetylation (mediated by histone deacetylases) directly influence important transcription factors in the monocyte-macrophage system by dynamically modulating chromatin accessibility. This review systematically examines the epigenetic network involving histone acetylation and deacetylation monocyte-macrophage, exploring its translational potential in bone-related diseases.

Indexed as

Bone DiseasesEpigenesis, GeneticHistonesMacrophagesMonocytesAcetylationAnimalsHumansHistonesbone homeostasishistone acetylationmononuclear phagocyteorthopedic diseases

Identifiers

PMID41522338
PMCPMC12780946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.