Evidence map›Paper›PMID 41522339›Full record

ArticleInternational journal of biological sciences2026

rBCG-LTAK63 Outperforms BCG in Bladder Cancer Immunotherapy: Dendritic and T Cell Coordination Drives Superior Tumor Control in a Mouse Model.

Matheus Ferreira de Almeida, Bruna Gennari Rosa, Daniela Delechiave, Lucas Francisco Annequin, Lazaro Moreira Marques-Neto, Monalisa Martins Trentini, Johanna Christine van Vliet, Isabelle Carolina Cotrim Gozzi, Ana Carolina de Oliveira Carvalho, Dunia Rodriguez and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matheus Ferreira de AlmeidaVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Bruna Gennari RosaVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Daniela DelechiaveVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Lucas Francisco AnnequinVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Lazaro Moreira Marques-NetoVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Monalisa Martins TrentiniVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Johanna Christine van VlietVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Isabelle Carolina Cotrim GozziVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Ana Carolina de Oliveira CarvalhoVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Dunia RodriguezVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Lennon Ramos PereiraVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Giana Carla GaboardiVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Luís Carlos de Souza FerreiraDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Luciana Cezar de Cerqueira LeiteVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Ana Carolina Ramos MorenoVaccine Development Laboratory, Butantan Institute, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacillus Calmette-Guérin (BCG) remains the standard treatment for non-muscle invasive bladder cancer (NMIBC), yet approximately 30% of patients fail to respond. To enhance therapeutic efficacy, we developed rBCG-LTAK63, a recombinant BCG strain, as a novel immunotherapeutic candidate.

Indexed as

BCG VaccineDendritic CellsImmunotherapyMycobacterium bovisT-LymphocytesUrinary Bladder NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorCoculture TechniquesFemaleHumansLymphocyte ActivationMiceMice, Inbred C57BLNon-Muscle Invasive Bladder NeoplasmsBCG VaccineBCGbladder cancerimmune responseimmunotherapyrecombinant BCG

Identifiers

PMID41522339
PMCPMC12781081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.