Evidence map›Paper›PMID 41522348›Full record

ArticleInternational journal of biological sciences2026

Dual Phosphorylation of STAT1 at Y701/S727 by TNFα Drives AIM2-Mediated PANoptosis of Renal Tubular Epithelial Cells and Fibrotic Progression in Renal Allografts.

Qianguang Han, Jiawen Liu, Jianjian Zhang, Qinghuan Shen, Junqi Zhang, Shuang Fei, Hao Chen, Li Sun, Zhengkai Huang, Zhijian Han and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qianguang HanDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Jiawen LiuDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Jianjian ZhangDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Qinghuan ShenDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Junqi ZhangDepartment of Urology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210028, China.
Shuang FeiDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Hao ChenDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Li SunDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Zhengkai HuangDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Zhijian HanDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Jun TaoDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Min GuDepartment of Urology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210028, China.
Xiaobing JuDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Ruoyun TanDepartment of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal allograft interstitial fibrosis, a key pathological feature of chronic renal allograft dysfunction (CAD), is a critical determinant of long-term graft survival. However, its underlying molecular mechanisms remain incompletely understood. This study uncovers the central role of programmed cell death, particularly the novel PANoptosis modality, in the progression of CAD. PANoptosis integrates features of pyroptosis, apoptosis, and necroptosis, but does not fit within the confines of any single pathway, with its mechanisms previously undefined. By analyzing cell death patterns in CAD tissues through single-cell sequencing and validating findings via

Indexed as

Epithelial CellsKidney TransplantationKidney TubulesSTAT1 Transcription FactorTumor Necrosis Factor-alphaAllograftsAnimalsFibrosisHumansMaleMicePhosphorylationSTAT1 Transcription FactorTumor Necrosis Factor-alphaAIM2chronic renal graft dysfunction (CAD)PANoptosisSTAT1TNF-α

Identifiers

PMID41522348
PMCPMC12780947

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.