Evidence map›Paper›PMID 41522352›Full record

ArticleInternational journal of biological sciences2026

DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR.

Ying Liu, Yangyang Li, Xiaowei Quan, Jiayi Zhang, Zhicong Wang, Zhaoyuan Hou, Herbert Yu, Haipeng Liu, Tengteng Zhu, Biyun Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying LiuHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yangyang LiHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiaowei QuanHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jiayi ZhangHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhicong WangHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhaoyuan HouFaculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu 96813, HI, USA.
Haipeng LiuInnovation and Incubation Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Tengteng ZhuHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Biyun QianHongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung adenocarcinoma (LUAD) progression involves multistep molecular pathogenesis, with many critical mediators of malignant transformation yet to be fully characterized. Building upon our previous discovery of discoidin, CUB and LCCL domain containing 1 (DCBLD1) as a novel LUAD risk-associated gene, we systematically investigated its function and underlying mechanisms in LUAD. Intriguingly, DCBLD1 overexpression promotes cellular transformation in both bronchial epithelial cells and EGFR

Indexed as

Adenocarcinoma of LungLung NeoplasmsProtein Tyrosine Phosphatase, Non-Receptor Type 1AnimalsCarcinogenesisErbB ReceptorsHumansMicePhosphorylationSignal TransductionErbB ReceptorsProtein Tyrosine Phosphatase, Non-Receptor Type 1DCBLD1EGFRlung adenocarcinomaPTP1Btumorigenesis

Identifiers

PMID41522352
PMCPMC12781078

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.