Evidence map›Paper›PMID 41522362›Full record

ArticleInternational journal of biological sciences2026

ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming.

Sibei Tao, Chenzhou Wu, Fanyuan Yu, Lina Yang, Lingzhi Li, Fan Guo, Ting Xiang, Liang Ma, Ping Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sibei TaoDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Chenzhou WuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
Fanyuan YuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
Lina YangDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Lingzhi LiDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Fan GuoDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Ting XiangDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Liang MaDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Ping FuDivision of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney fibrosis is the most common pathology and endpoint of CKD. Unraveling the mechanisms of kidney fibrosis is crucial. Activating transcription factors (ATFs) are implicated in a range of kidney diseases, but their roles in kidney fibrosis remain underexplored. In our investigation, employing an unbiased screening of ATF expression in fibrotic kidneys via analyzing single-cell and bulk RNA sequencing, we identified that ATF3 as the key player, markedly upregulated in damaged tubular epithelial cells (TECs). Crucially, ATF3 deletion in mice markedly attenuated kidney fibrosis and abrogated fibrotic traits in injured TECs. At the molecular level, ATF3 was found to recruit HDAC6 to the

Indexed as

Activating Transcription Factor 3Epigenesis, GeneticFibrosisHistone Deacetylase 6KidneyKidney DiseasesAnimalsEpithelial CellsMiceSignal TransductionSmad3 ProteinSmad7 ProteinTransforming Growth Factor betaActivating Transcription Factor 3Atf3 protein, mouseHdac6 protein, mouseHistone Deacetylase 6Smad3 ProteinSmad3 protein, mouseSmad7 ProteinSmad7 protein, mouseTransforming Growth Factor betaATF3epigenetic reprogrammingHDAC6kidney fibrosis

Identifiers

PMID41522362
PMCPMC12781174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.