ArticleChemical science2026
Metal-free visible-light carbonylation of alkyl iodides to amides
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A visible-light-driven, metal-free carbonylation of unactivated alkyl iodides is reported, enabling the direct synthesis of 35 structurally diverse amides in good to excellent yields. The reaction shows broad functional-group tolerance toward both amines and alkyl iodides, including bioisosteric motifs and complex natural product derivatives, underscoring its potential for late-stage functionalization. Mechanistic investigations combining flash photolysis, spectroelectrochemistry, irradiated thin-layer cyclic voltammetry, and EPR spectroscopy reveal a consecutive photoinduced electron transfer (ConPET) mechanism that diverges from conventional single-photon photoredox catalysis. DFT calculations elucidate the key radical carbonylation steps governing reactivity and selectivity. This sustainable and operationally simple method offers a transition-metal-free approach to carbonylation, expanding the toolbox for highly reducing transformations under mild conditions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.