Evidence map›Paper›PMID 41522863›Full record

ArticleChemical science2026

Unveiling the molecular dynamics of a nitrile-containing 5-lipoxygenase-activating protein antagonist in primary macrophages through Raman spectroscopy.

Constanze Schultz, Paul Mike Jordan, Philipp Dahlke, Zehra Tuğçe Gür Maz, Erden Banoğlu, Tobias Meyer-Zedler, Michael Schmitt, Oliver Werz, Juergen Popp

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Constanze SchultzLeibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI) Albert-Einstein-Str. 9 07745 Jena Germany juergen.popp@uni-jena.de.ORCID https://orcid.org/0009-0009-6126-3334
Paul Mike JordanInstitute of Pharmaceutical Chemistry, Friedrich Schiller University Jena Philosophenweg 14 07743 Jena Germany.ORCID https://orcid.org/0000-0002-8364-4236
Philipp DahlkeInstitute of Pharmaceutical Chemistry, Friedrich Schiller University Jena Philosophenweg 14 07743 Jena Germany.ORCID https://orcid.org/0000-0003-2865-9811
Zehra Tuğçe Gür MazDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University Taç Sok. No:3 Yenimahalle 06560 Ankara Turkey.
Erden BanoğluDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University Taç Sok. No:3 Yenimahalle 06560 Ankara Turkey.
Tobias Meyer-ZedlerLeibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI) Albert-Einstein-Str. 9 07745 Jena Germany juergen.popp@uni-jena.de.ORCID https://orcid.org/0000-0001-6740-629X
Michael SchmittInstitute of Physical Chemistry (IPC) and Abbe Center of Photonics (ACP), Member of the Leibniz Center for Photonics in Infection Research (LPI), Friedrich Schiller University Jena Helmholtzweg 4 07743 Jena Germany.ORCID https://orcid.org/0000-0002-3807-3630
Oliver WerzInstitute of Pharmaceutical Chemistry, Friedrich Schiller University Jena Philosophenweg 14 07743 Jena Germany.
Juergen PoppLeibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI) Albert-Einstein-Str. 9 07745 Jena Germany juergen.popp@uni-jena.de.ORCID https://orcid.org/0000-0003-4257-593X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nitrile (-C[triple bond, length as m-dash]N) functional group is a versatile pharmacophore motif that also serves as an intrinsic, bioorthogonal Raman tag in the silent wavenumber region (1800-2700 cm

Identifiers

PMID41522863
PMCPMC12784294

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.