ArticleTaiwan journal of ophthalmology
Conjunctival microvascular alterations in dry eye disease: A comparative study of Sjögren's and non-Sjögren's subtypes.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Molecular Target Discovery and Systemic Mechanism Analysis of Teriflunomide for Dry Eye Disease.Current issues in molecular biology · 2026Article
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8 authors.
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Abstract
purposeConjunctival microvasculature is associated with ocular and systemic diseases. Previous studies have reported increased blood flow velocity (BFV), blood flow rate (BFR), vessel density, and diameter in dry eye disease (DED). This study aimed to compare bulbar conjunctival microvascular morphology and hemodynamics between patients with DED with and without Sjögren's dry eye (SSDE and NSDE) who had comparable symptoms, and to assess their correlations with Meibomian gland dysfunction (MGD) parameters. MATERIALS AND
methodsIn this prospective study, conjunctival imaging for the left eyes of patients with DED was performed using a previously developed optical system incorporating Attention-UNet-based vessel segmentation and a validated two-step motion-correction pipeline. Tear film lipid layer thickness measurement and meibography were performed using the LipiView® II Ocular Surface Inferometer. Microvascular parameters, including BFV, BFR, and diameter, were quantified.
resultsThe mean microvessel diameter for the SSDE group (12.985 ± 2.478 μm) was significantly higher than that for NSDE (9.431 ± 3.982 μm) (
conclusionThese findings reveal distinct conjunctival microvascular signatures in patients with SSDE, and support vessel diameter as a discriminator. The association between hemodynamic changes and MGD parameters in the NSDE group underscores the interplay between MGD and conjunctival microcirculation in NSDE. The differences in microvasculature identified in this study may serve as valuable biomarkers for DED subtype classification and the development of personalized treatment.
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